ArticleMolecular biology of the cell2009
Katanin knockdown supports a role for microtubule severing in release of basal bodies before mitosis in Chlamydomonas.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Shedding of ciliary vesicles at a glance.Journal of cell science · 2022Article
- The short flagella 1 (SHF1) gene inMolecular biology of the cell · 2022Article
- Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.PLoS biology · 2019Article
- Mechanism and Regulation of Centriole and Cilium Biogenesis.Annual review of biochemistry · 2019Review
- Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The regulation of cilium assembly and disassembly in development and disease.Development (Cambridge, England) · 2018Review
- The role of katanin p60 in breast cancer bone metastasis.Oncology letters · 2018Article
- Cilium assembly and disassembly.Nature cell biology · 2016Review
- Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.Molecular & cellular proteomics : MCP · 2016Article
- A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division.eLife · 2016Article
- Cellular Mechanisms of Ciliary Length Control.Cells · 2016Review
- A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells.Cellular and molecular life sciences : CMLS · 2016Article
- KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome.Genome biology · 2015Article
- The Chlamydomonas cell cycle.The Plant journal : for cell and molecular biology · 2015Review
- Katanin p80 regulates human cortical development by limiting centriole and cilia number.Neuron · 2014Article
- Communication, the centrosome and the immunological synapse.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Article
- N-terminal phosphorylation of p60 katanin directly regulates microtubule severing.Journal of molecular biology · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Katanin is a microtubule-severing protein that participates in the regulation of cell cycle progression and in ciliary disassembly, but its precise role is not known for either activity. Our data suggest that in Chlamydomonas, katanin severs doublet microtubules at the proximal end of the flagellar transition zone, allowing disengagement of the basal body from the flagellum before mitosis. Using an RNA interference approach we have discovered that severe knockdown of the p60 subunit of katanin, KAT1, is achieved only in cells that also carry secondary mutations that disrupt ciliogenesis. Importantly, we observed that cells in the process of cell cycle-induced flagellar resorption sever the flagella from the basal bodies before resorption is complete, and we find that this process is defective in KAT1 knockdown cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.