ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Adaptation of firing rate and spike-timing precision in the avian cochlear nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Patch-seq analysis reveals transcriptomic correlates of neuronal firing rate adaptation across subtypes and species.iScience · 2026Article
- In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis.bioRxiv : the preprint server for biology · 2025Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- Spike threshold adaptation diversifies neuronal operating modes in the auditory brain stem.Journal of neurophysiology · 2019Article
- Article
- Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex.Journal of neurophysiology · 2018Article
- SK channel subtypes enable parallel optimized coding of behaviorally relevant stimulus attributes: A review.Channels (Austin, Tex.) · 2017Review
- Self-motion evokes precise spike timing in the primate vestibular system.Nature communications · 2016Article
- Tonotopic Optimization for Temporal Processing in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Developmental expression of Kv1 voltage-gated potassium channels in the avian hypothalamus.Neuroscience letters · 2016Article
- Spike timing precision changes with spike rate adaptation in the owl's auditory space map.Journal of neurophysiology · 2015Article
- Dynamic dendritic compartmentalization underlies stimulus-specific adaptation in an insect neuron.Journal of neurophysiology · 2015Article
- Emphasis of spatial cues in the temporal fine structure during the rising segments of amplitude-modulated sounds II: single-neuron recordings.Journal of neurophysiology · 2014Article
- Reliability of spike and burst firing in thalamocortical relay cells.Journal of computational neuroscience · 2013Article
- Intrinsic firing properties in the avian auditory brain stem allow both integration and encoding of temporally modulated noisy inputs in vitro.Journal of neurophysiology · 2012Article
- Adaptation of spike timing precision controls the sensitivity to interaural time difference in the avian auditory brainstem.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Frequency-specific, location-nonspecific adaptation of interaural time difference sensitivity.Hearing research · 2012Article
- Dynamic interaction of Ih and IK-LVA during trains of synaptic potentials in principal neurons of the medial superior olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Tonotopic tuning in a sound localization circuit.Journal of neurophysiology · 2010Article
- A modeling study of the effects of membrane afterhyperpolarization on spike interval statistics and on ILD encoding in the lateral superior olive.Journal of neurophysiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Adaptation is commonly defined as a decrease in response to a constant stimulus. In the auditory system such adaptation is seen at multiple levels. However, the first-order central neurons of the interaural time difference detection circuit encode information in the timing of spikes rather than the overall firing rate. We investigated adaptation during in vitro whole-cell recordings from chick nucleus magnocellularis neurons. Injection of noisy, depolarizing current caused an increase in firing rate and a decrease in spike time precision that developed over approximately 20 s. This adaptation depends on sustained depolarization, is independent of firing, and is eliminated by alpha-dendrotoxin (0.1 microM), implicating slow inactivation of low-threshold voltage-activated K+ channels as its mechanism. This process may alter both firing rate and spike-timing precision of phase-locked inputs to coincidence detector neurons in nucleus laminaris and thereby adjust the precision of sound localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.