ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Synapsins are late activity-induced genes regulated by birdsong.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.Scientific reports · 2020Article
- Temporal Profile of Brain Gene Expression After Prey Catching Conditioning in an Anuran Amphibian.Frontiers in neuroscience · 2019Article
- Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse.The Journal of comparative neurology · 2015Article
- The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.Neuroscience and biobehavioral reviews · 2015Review
- Mechanistic basis and functional roles of long-term plasticity in auditory neurons induced by a brain-generated estrogen.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Estradiol-dependent modulation of serotonergic markers in auditory areas of a seasonally breeding songbird.Behavioral neuroscience · 2012Article
- Noradrenergic control of gene expression and long-term neuronal adaptation evoked by learned vocalizations in songbirds.PloS one · 2012Article
- Serotonin-mediated synapsin expression is necessary for long-term facilitation of the Aplysia sensorimotor synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Singing under the influence: examining the effects of nutrition and addiction on a learned vocal behavior.Molecular neurobiology · 2011Review
- Estradiol-dependent modulation of auditory processing and selectivity in songbirds.Frontiers in neuroendocrinology · 2011Review
- Article
- Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Brain expression and song regulation of the cholecystokinin gene in the zebra finch (Taeniopygia guttata).The Journal of comparative neurology · 2011Article
- Food for song: expression of c-Fos and ZENK in the zebra finch song nuclei during food aversion learning.PloS one · 2011Article
- Retinal lesions induce layer-specific Fos expression changes in cat area 17.Experimental brain research · 2010Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The consolidation of long-lasting sensory memories requires the activation of gene expression programs in the brain. Despite considerable knowledge about the early components of this response, little is known about late components (i.e., genes regulated 2-6 h after stimulation) and the relationship between early and late genes. Birdsong represents one of the best natural behaviors to study sensory-induced gene expression in awake, freely behaving animals. Here we show that the expression of several isoforms of synapsins, a group of phosphoproteins thought to regulate the dynamics of synaptic vesicle storage and release, is induced by auditory stimulation with birdsong in the caudomedial nidopallium (NCM) of the zebra finch (Taeniopygia guttata) brain. This induction occurs mainly in excitatory (non-GABAergic) neurons and is modulated (suppressed) by early song-inducible proteins. We also show that ZENK, an early song-inducible transcription factor, interacts with the syn3 promoter in vivo, consistent with a direct regulatory effect and an emerging novel view of ZENK action. These results demonstrate that synapsins are a late component of the genomic response to neuronal activation and that their expression depends on a complex set of regulatory interactions between early and late regulated genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.