ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Adult neurogenesis, mental health, and mental illness: hope or hype?
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it, 252 citations in OpenAlex.
- Antenatal depression: a rationale for studying exercise.Depression and anxiety · 2011Pooled it
- Differential neuronal vulnerability varies according to specific cardiopulmonary bypass insult in a porcine survival model.The Journal of thoracic and cardiovascular surgery · 2010Pooled it
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
- Altered Hippocampal Activation in Seizure-ProneeNeuro · 2024Article
- Altered hippocampal activation in seizure-pronebioRxiv : the preprint server for biology · 2023Article
- Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress.Biomedicines · 2023Article
- Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome.BMC medicine · 2022Article
- The Science of Learning and Art of Education in Cardiology Fellowship.Methodist DeBakey cardiovascular journal · 2022Review
- Progression of behavioral deficits during periadolescent development differs in female and male DISC1 knockout rats.Genes, brain, and behavior · 2022Article
- A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology.Molecular psychiatry · 2022Review
- Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition.Molecular psychiatry · 2021Article
- Neurobiological effects of phospholipidsNeurobiology of stress · 2020Article
- Cytoarchitecture of the mouse brain by high resolution diffusion magnetic resonance imaging.NeuroImage · 2020Article
- The Effects of 1-Hz rTMS on Emotional Behavior and Dendritic Complexity of Mature and Newly Generated Dentate Gyrus Neurons in Male Mice.International journal of environmental research and public health · 2020Article
- Intranasal Insulin: a Treatment Strategy for Addiction.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Vitamin D and Depression in Women: A Mini-review.Current neuropharmacology · 2020Review
- Therapeutic Plasticity of Neural Stem Cells.Frontiers in neurology · 2020Review
- Image-guided cranial irradiation-induced ablation of dentate gyrus neurogenesis impairs extinction of recent morphine reward memories.Hippocampus · 2019Article
- Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice.Oncotarget · 2018Article
- Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease.Neural plasticity · 2018Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding "normal" adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.