ArticleJournal of neurophysiology2009
Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 36 citations in OpenAlex.
- Voltage to Calcium Transformation Enhances Direction Selectivity inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Conservation of cardiac L-type CaJournal of molecular and cellular cardiology · 2018Article
- Electrophysiological analysis of synaptic transmission in Drosophila.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- FlpStop, a tool for conditional gene control ineLife · 2017Article
- Spontaneous CaFrontiers in molecular neuroscience · 2017Article
- Article
- Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.Brain research · 2014Article
- A biophysical analysis of mitochondrial movement: differences between transport in neuronal cell bodies versus processes.Traffic (Copenhagen, Denmark) · 2014Article
- Article
- Cav3-type α1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs.Journal of neurophysiology · 2013Article
- Early olfactory processing in Drosophila: mechanisms and principles.Annual review of neuroscience · 2013Review
- In vitro imaging of primary neural cell culture from Drosophila.Nature protocols · 2013Article
- Preparation of Drosophila central neurons for in situ patch clamping.Journal of visualized experiments : JoVE · 2012Article
- Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons.The Journal of physiology · 2012Article
- TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila.PloS one · 2012Article
- Understanding the functional consequences of synaptic specialization: insight from the Drosophila antennal lobe.Current opinion in neurobiology · 2011Review
- 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.Nature reviews. Neuroscience · 2010Review
- Activity-dependent modulation of neural circuit synaptic connectivity.Frontiers in molecular neuroscience · 2009Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Voltage-gated calcium channels containing alpha1 subunits encoded by Ca(v)2 family genes are critical in regulating release of neurotransmitter at chemical synapses. In Drosophila, cac is the only Ca(v)2-type gene. Cacophony (CAC) channels are localized in motor neuron terminals where they have been shown to mediate evoked, but not AP-independent, release of glutamate at the larval neuromuscular junction (NMJ). Cultured embryonic neurons also express CAC channels, but there is no information about the properties of CAC-mediated currents in adult brain nor how these channels regulate transmission in central neural circuits where fast excitatory synaptic transmission is predominantly cholinergic. Here we report that wild-type neurons cultured from late stage pupal brains and antennal lobe projection neurons (PNs) examined in adult brains, express calcium currents with two components: a slow-inactivating current sensitive to the spider toxin Plectreurys toxin II (PLTXII) and a fast-inactivating PLTXII-resistant component. CAC channels are the major contributors to the slow-inactivating PLTXII-sensitive current based on selective reduction of this component in hypomorphic cac mutants (NT27 and TS3). Another characteristic of cac mutant neurons both in culture and in whole brain recordings is a reduced cholinergic miniature excitatory postsynaptic current frequency that is mimicked in wild-type neurons by acute application of PLTXII. These data demonstrate that cac encoded Ca(v)2-type calcium channels regulate action potential (AP)-independent release of neurotransmitter at excitatory cholinergic synapses in the adult brain, a function not predicted from studies at the larval NMJ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.