ArticleJournal of virology2009
The C-terminal domains of adenovirus serotype 5 protein IX assemble into an antiparallel structure on the facets of the capsid.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenoviruses.Science advances · 2021Article
- A tropism-transformed Oncolytic Adenovirus with Dual Capsid Modifications for enhanced Glioblastoma Therapy.Journal of Cancer · 2020Article
- Atomic Structures of Minor Proteins VI and VII in Human Adenovirus.Journal of virology · 2017Article
- Bovine adenovirus type 3 virions cannot be rescuedJournal of veterinary science · 2017Article
- Cellular electron cryo tomography and in situ sub-volume averaging reveal the context of microtubule-based processes.Journal of structural biology · 2017Article
- A novel capsid-modified oncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy by intravenous route.Oncotarget · 2016Article
- Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k.Journal of virology · 2015Article
- Review
- Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Latest insights on adenovirus structure and assembly.Viruses · 2012Review
- Unnatural amino acid incorporation onto adenoviral (Ad) coat proteins facilitates chemoselective modification and retargeting of Ad type 5 vectors.Journal of virology · 2011Article
- Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging.PloS one · 2011Article
- Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors.Virology · 2011Article
- Retargeting of adenovirus vectors through genetic fusion of a single-chain or single-domain antibody to capsid protein IX.Journal of virology · 2010Article
- Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks.Science (New York, N.Y.) · 2010Article
- In vitro dynamic visualization analysis of fluorescently labeled minor capsid protein IX and core protein V by simultaneous detection.Journal of molecular biology · 2010Article
- Adenovirus.Current topics in microbiology and immunology · 2010Review
- Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect.Journal of virology · 2009Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenovirus serotype 5 protein IX (pIX) has two domains connected by a flexible linker. Three N-terminal domains form triskelions on the capsid facets that cement hexons together, and the C-terminal domains of four monomers form complexes toward the facet periphery. Here we present a cryoelectron microscopy structure of recombinant adenovirus with a peptide tag added to the C terminus of pIX. The structure, made up by several C termini of pIX, is longer at both ends than the wild-type protein, and Fabs directed against the tag bind to both ends of the oligomer, demonstrating that the pIX C termini associate in an antiparallel manner.
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