ArticleDevelopment (Cambridge, England)2008
Canonical Wnt signaling is required for the maintenance of dorsal retinal identity.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Integration of in situ hybridization and scRNA-seq data provides a 2D topographical map of the developing retina across species.bioRxiv : the preprint server for biology · 2026Article
- Wnt5a regulates the expression of developmental genes in the adult retina following optic nerve crush injury.Histology and histopathology · 2025Article
- Repurposing development genes for axonal regeneration following injury: Examining the roles of Wnt signaling.Frontiers in cell and developmental biology · 2024Review
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- Expanding the phenotypic spectrum and clinical severity associated with WLS gene.Journal of human genetics · 2023Article
- Porcn is essential for growth and invagination of the mammalian optic cup.Frontiers in cell and developmental biology · 2022Article
- BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish.International journal of molecular sciences · 2021Article
- CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids.Frontiers in cell and developmental biology · 2021Article
- In Vivo Analysis of Optic Fissure Fusion in Zebrafish: Pioneer Cells, Basal Lamina, Hyaloid Vessels, and How Fissure Fusion is Affected by BMP.International journal of molecular sciences · 2020Article
- Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt.Open biology · 2019Article
- Holt-Oram Syndrome With Multiple Cardiac Abnormalities.Cardiology research · 2018Article
- Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye.PLoS genetics · 2018Article
- Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway.Developmental biology · 2018Article
- Article
- Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells.Stem cells (Dayton, Ohio) · 2016Article
- Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.Investigative ophthalmology & visual science · 2016Article
- A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma.Human molecular genetics · 2016Article
- WNT/β-Catenin Signaling in Vertebrate Eye Development.Frontiers in cell and developmental biology · 2016Review
- Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish.PLoS genetics · 2015Article
- Neural retina identity is specified by lens-derived BMP signals.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Accurate retinotectal axon pathfinding depends upon the correct establishment of dorsal-ventral retinal polarity. We show that dorsal retinal gene expression is regulated by Wnt signaling in the dorsal retinal pigment epithelium (RPE). We find that a Wnt reporter transgene and Wnt pathway components are expressed in the dorsal RPE beginning at 14-16 hours post-fertilization. In the absence of Wnt signaling, tbx5 and Bmp genes initiate normal dorsal retinal expression but are not maintained. The expression of these genes is rescued by the downstream activation of Wnt signaling, and tbx5 is rescued by Bmp signaling. Furthermore, activation of Wnt signaling cannot rescue tbx5 in the absence of Bmp signaling, suggesting that Wnt signaling maintains dorsal retinal gene expression by regulating Bmp signaling. We present a model in which dorsal RPE-derived Wnt activity maintains the expression of Bmp ligands in the dorsal retina, thus coordinating the patterning of these two ocular tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.