ArticleProceedings of the National Academy of Sciences of the United States of America2008
Peptide antisense nanoparticles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Enhancing Endosomal Escape and Gene Regulation Activity for Spherical Nucleic Acids.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Site-directed dual bioprobes inducing single-step nano-sandwich assay for the detection of cardiac troponin I.Mikrochimica acta · 2022Article
- Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides.Molecular pharmaceutics · 2021Article
- Functionalized Gold Nanoparticles for the Detection of C-Reactive Protein.Nanomaterials (Basel, Switzerland) · 2018Review
- Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.Nature chemistry · 2017Review
- Liposomal Spherical Nucleic Acids for Regulating Long Noncoding RNAs in the Nucleus.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Quantification and real-time tracking of RNA in live cells using Sticky-flares.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bioresponsive antisense DNA gold nanobeacons as a hybrid in vivo theranostics platform for the inhibition of cancer cells and metastasis.Scientific reports · 2015Article
- Rational design of gold nanocarrier for the delivery of JAG-1 peptide.Journal of nanobiotechnology · 2015Article
- Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing.The Analyst · 2015Article
- Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures.Molecular pharmaceutics · 2013Article
- Antibody-linked spherical nucleic acids for cellular targeting.Journal of the American Chemical Society · 2012Article
- Monolayer coated gold nanoparticles for delivery applications.Advanced drug delivery reviews · 2012Review
- Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux.ACS nano · 2012Article
- Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA-nanoparticle conjugates.ACS nano · 2011Article
- Radiolabeled oligonucleotides for antisense imaging.Current organic synthesis · 2011Article
- Beauty is skin deep: a surface monolayer perspective on nanoparticle interactions with cells and bio-macromolecules.Small (Weinheim an der Bergstrasse, Germany) · 2011Review
- Functionalized Gold Nanoparticles and Their Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2011Review
- Scavenger receptors mediate cellular uptake of polyvalent oligonucleotide-functionalized gold nanoparticles.Bioconjugate chemistry · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have designed a heterofunctionalized nanoparticle conjugate consisting of a 13-nm gold nanoparticle (Au NP) containing both antisense oligonucleotides and synthetic peptides. The synthesis of this conjugate is accomplished by mixing thiolated oligonucleotides and cysteine-terminated peptides with gold nanoparticles in the presence of salt, which screens interactions between biomolecules, yielding a densely functionalized nanomaterial. By controlling the stoichiometry of the components in solution, we can control the surface loading of each biomolecule. The conjugates are prepared easily and show perinuclear localization and an enhanced gene regulation activity when tested in a cellular model. This heterofunctionalized structure represents a new strategy for preparing nanomaterials with potential therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.