ArticleProceedings of the National Academy of Sciences of the United States of America2008
Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Histological and Transcriptomic Insights into Rugose Surface Formation in Pepper (Plants (Basel, Switzerland) · 2025Article
- Prefoldin Subunits and Its Associate Partners: Conservations and Specificities in Plants.Plants (Basel, Switzerland) · 2024Review
- Pathogen-derived mechanical cues potentiate the spatio-temporal implementation of plant defense.BMC biology · 2022Article
- Prefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein-1.FEBS open bio · 2022Article
- Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms.Frontiers in neuroscience · 2022Article
- Review
- A genetic approach reveals different modes of action of prefoldins.Plant physiology · 2021Article
- The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.PLoS genetics · 2020Article
- Prefoldins contribute to maintaining the levels of the spliceosome LSM2-8 complex through Hsp90 in Arabidopsis.Nucleic acids research · 2020Article
- Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus.Plant biotechnology journal · 2020Article
- The functions and mechanisms of prefoldin complex and prefoldin-subunits.Cell & bioscience · 2020Review
- Article
- Shot-Gun Proteomic Analysis on Roots of ArabidopsisInternational journal of molecular sciences · 2018Article
- Proteomic discovery of HPlanta · 2018Article
- Katanin: A Sword Cutting Microtubules for Cellular, Developmental, and Physiological Purposes.Frontiers in plant science · 2017Review
- Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.Scientific reports · 2016Article
- Regulation of developmental and environmental signaling by interaction between microtubules and membranes in plant cells.Protein & cell · 2016Review
- Analysis of the Prefoldin Gene Family in 14 Plant Species.Frontiers in plant science · 2016Article
- Microtubules in plants.The arabidopsis book · 2015Article
- Nuclear functions of prefoldin.Open biology · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 mutant exhibits a range of microtubule defects, including hypersensitivity to oryzalin, defects in cell division, cortical array organization, and microtubule dynamicity. Consistent with phenotypic analysis, proteomic analysis indicates several isoforms of tubulins were reduced in pfd6-1. These results support the concept that the function of microtubules is critically dependent on the absolute amount of tubulins.
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Registered trials
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