ArticleProceedings of the National Academy of Sciences of the United States of America2008
Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 66 citations in OpenAlex.
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- P2X7R+CD8αβiScience · 2026Article
- Intraepithelial Lymphocytes and LAIR1 Expression in Celiac Disease.Biomedicines · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis.Science immunology · 2025Article
- Article
- Ligands for Intestinal Intraepithelial T Lymphocytes in Health and Disease.Pathogens (Basel, Switzerland) · 2025Review
- Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes.Clinical and experimental immunology · 2023Review
- CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells.The Journal of experimental medicine · 2022Article
- A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.Science (New York, N.Y.) · 2022Article
- Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.The Journal of experimental medicine · 2022Article
- Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.Frontiers in immunology · 2022Review
- Development and function of natural TCRFrontiers in immunology · 2022Review
- Cdx2 regulates immune cell infiltration in the intestine.Scientific reports · 2021Article
- Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes.Mucosal immunology · 2021Article
- Unconventional Intestinal Intraepithelial Lymphocytes in Health and Disease.Critical reviews in immunology · 2021Review
- Mechanisms of activation of innate-like intraepithelial T lymphocytes.Mucosal immunology · 2020Review
- Osteopontin and iCD8α Cells Promote Intestinal Intraepithelial Lymphocyte Homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Intestinal intraepithelial lymphocytes (IEL) bear a partially activated phenotype that permits them to rapidly respond to antigenic insults. However, this phenotype also implies that IEL must be highly controlled to prevent misdirected immune reactions. It has been suggested that IEL are regulated through the interaction of the CD8alpha alpha homodimer with the thymus leukemia (TL) antigen expressed by intestinal epithelial cells. We have generated and characterized mice genetically-deficient in TL expression. Our findings show that TL expression has a critical role in maintaining IEL effector functions. Also, TL deficiency accelerated colitis in a genetic model of inflammatory bowel disease. These findings reveal an important regulatory role of TL in controlling IEL function and intestinal inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.