ArticleNutrition and cancer2008
Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.
Article in Nutrition and cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 118 citations in OpenAlex.
- Gallic Acid Enhances Carboplatin-Induced Antitumoral Responses in Cervical Cancer Cells Through Oxidative Stress-Associated Mitochondrial and Apoptotic Mechanisms.Biomedicines · 2026Article
- Development of an efficient method for separation and purification of cordycepin from liquid fermentation ofHeliyon · 2023Article
- Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation.International journal of molecular sciences · 2022Review
- Phenol Derivatives Obtained from Grape Seed Extract Show Virucidal Activity against Murine Norovirus.Molecules (Basel, Switzerland) · 2022Article
- The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc.International journal of molecular sciences · 2022Review
- RETRACTED:Metabolites · 2022Article
- Correlation between antioxidant and anticancer activity and phenolic profile of new Apulian table grape genotypes (Frontiers in plant science · 2022Article
- HRMS Characterization, Antioxidant and Cytotoxic Activities of Polyphenols inMolecules (Basel, Switzerland) · 2021Article
- Polyphenolic QTOF-ESI MS Characterization and the Antioxidant and Cytotoxic Activities ofMolecules (Basel, Switzerland) · 2021Article
- Phenolic Fractions fromAntioxidants (Basel, Switzerland) · 2020Article
- Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.Antioxidants (Basel, Switzerland) · 2020Article
- Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers.Molecules (Basel, Switzerland) · 2020Review
- Flavonoid and Non-Flavonoid Compounds of Autumn Royal and Egnatia Grape Skin Extracts Affect Membrane PUFA's Profile and Cell Morphology in Human Colon Cancer Cell Lines.Molecules (Basel, Switzerland) · 2020Article
- Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines.Nutrients · 2020Article
- Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo.Nutrients · 2019Article
- Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines.Food science & nutrition · 2019Article
- Esculetin enhances the inhibitory effect of 5-Fluorouracil on the proliferation, migration and epithelial-mesenchymal transition of colorectal cancer.Cancer biomarkers : section A of Disease markers · 2019Article
- Bio-Based Compounds from Grape Seeds: A Biorefinery Approach.Molecules (Basel, Switzerland) · 2018Review
- Cancer Chemopreventive Potential of Procyanidin.Toxicological research · 2017Review
- Prodelphinidins isolated from Chinese bayberry leaves induces apoptosis via the p53-dependent signaling pathways in OVCAR-3 human ovarian cancer cells.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
One approach to control colorectal cancer (CRC) is its preventive intervention by dietary agents or those consumed as supplements. However, because most of these products are often consumed by patients as an complementary and alternative medicine practice, a scientific base such as efficacy, mechanism, and standardized preparation needs to be developed. Grape seed extract (GSE) is one such supplement widely consumed by humans for its several health benefits. We reported recently that GSE inhibits CRC cell HT29 growth in culture and nude mice xenograft. Because GSE is available commercially through different vendors, here we assessed whether GSE from 2 different manufacturers produces comparable biological effects in a panel of human CRC cell lines. Our results show that irrespective of source, GSE strongly inhibits LoVo, HT29, and SW480 cell growth, with a G1 arrest in LoVo and HT29 cells but an S and/or G2/M arrest in SW480 cell cycle progression. GSE also induced Cip/p21 levels in all 3 cell lines. Furthermore, an induction of apoptosis was observed in all 3 cell lines by GSE. Taken together, our findings suggest that GSE could be an effective CAM agent against CRC possibly due to its strong growth inhibitory and apoptosis-inducing effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.