ArticleCognitive neurodynamics2008
Population based models of cortical drug response: insights from anaesthesia.
Article in Cognitive neurodynamics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Transient neocortical gamma oscillations induced by neuronal response modulation.Journal of computational neuroscience · 2020Article
- Transitions between asynchronous and synchronous states: a theory of correlations in small neural circuits.Journal of computational neuroscience · 2018Article
- Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers.Journal of visualized experiments : JoVE · 2018Article
- Human seizures couple across spatial scales through travelling wave dynamics.Nature communications · 2017Article
- How the cortico-thalamic feedback affects the EEG power spectrum over frontal and occipital regions during propofol-induced sedation.Journal of computational neuroscience · 2015Article
- A probabilistic method for determining cortical dynamics during seizures.Journal of computational neuroscience · 2015Article
- Emergence of spatially heterogeneous burst suppression in a neural field model of electrocortical activity.Frontiers in systems neuroscience · 2015Article
- Study of GABAergic extra-synaptic tonic inhibition in single neurons and neural populations by traversing neural scales: application to propofol-induced anaesthesia.Journal of computational neuroscience · 2014Article
- Emergence from general anesthesia and the sleep-manifold.Frontiers in systems neuroscience · 2014Article
- Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.Frontiers in systems neuroscience · 2014Article
- Computer simulations of synchrony and oscillations evoked by two coherent inputs.Cognitive neurodynamics · 2013Article
- Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions.Frontiers in computational neuroscience · 2013Article
- Modeling effect of GABAergic current in a basal ganglia computational model.Cognitive neurodynamics · 2012Article
- Dynamical changes in neurological diseases and anesthesia.Current opinion in neurobiology · 2012Review
- Genuine and spurious phase synchronization strengths during consciousness and general anesthesia.PloS one · 2012Article
- Article
- Effects of anesthetic agents on brain blood oxygenation level revealed with ultra-high field MRI.PloS one · 2012Article
- Dynamic causal models and physiological inference: a validation study using isoflurane anaesthesia in rodents.PloS one · 2011Article
- Effects of the anesthetic agent propofol on neural populations.Cognitive neurodynamics · 2010Article
- The electrocortical effects of enflurane: experiment and theory.Anesthesia and analgesia · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A great explanatory gap lies between the molecular pharmacology of psychoactive agents and the neurophysiological changes they induce, as recorded by neuroimaging modalities. Causally relating the cellular actions of psychoactive compounds to their influence on population activity is experimentally challenging. Recent developments in the dynamical modelling of neural tissue have attempted to span this explanatory gap between microscopic targets and their macroscopic neurophysiological effects via a range of biologically plausible dynamical models of cortical tissue. Such theoretical models allow exploration of neural dynamics, in particular their modification by drug action. The ability to theoretically bridge scales is due to a biologically plausible averaging of cortical tissue properties. In the resulting macroscopic neural field, individual neurons need not be explicitly represented (as in neural networks). The following paper aims to provide a non-technical introduction to the mean field population modelling of drug action and its recent successes in modelling anaesthesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.