ArticleSystems and synthetic biology2007
Simulation of developmental changes in action potentials with ventricular cell models.
Article in Systems and synthetic biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Model-based estimation of QT intervals of mouse fetal electrocardiogram.Biomedical engineering online · 2022Article
- Functional expression and pharmaceutical efficacy of cardiac-specific ion channels in human embryonic stem cell-derived cardiomyocytes.Scientific reports · 2017Article
- Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block.British journal of pharmacology · 2015Article
- Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study.The journal of physiological sciences : JPS · 2013Article
- Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes.Biomedical engineering online · 2012Article
- Functional expression of potassium channels in cardiomyocytes derived from embryonic stem cells.Research in pharmaceutical sciences · 2012Article
- Assessment of potassium current in Royan B(1) stem cell derived cardiomyocytes by patch-clamp technique.Research in pharmaceutical sciences · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During cardiomyocyte development, early embryonic ventricular cells show spontaneous activity that disappears at a later stage. Dramatic changes in action potential are mediated by developmental changes in individual ionic currents. Hence, reconstruction of the individual ionic currents into an integrated mathematical model would lead to a better understanding of cardiomyocyte development. To simulate the action potential of the rodent ventricular cell at three representative developmental stages, quantitative changes in the ionic currents, pumps, exchangers, and sarcoplasmic reticulum (SR) Ca(2+) kinetics were represented as relative activities, which were multiplied by conductance or conversion factors for individual ionic systems. The simulated action potential of the early embryonic ventricular cell model exhibited spontaneous activity, which ceased in the simulated action potential of the late embryonic and neonatal ventricular cell models. The simulations with our models were able to reproduce action potentials that were consistent with the reported characteristics of the cells in vitro. The action potential of rodent ventricular cells at different developmental stages can be reproduced with common sets of mathematical equations by multiplying conductance or conversion factors for ionic currents, pumps, exchangers, and SR Ca(2+) kinetics by relative activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.