ArticleCytotechnology2006
The role of recombinant proteins in the development of serum-free media.
Article in Cytotechnology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Refined production of egg-derived media additives enhances proliferation and differentiation of skeletal muscle satellite cell culture.Food science of animal resources · 2026Article
- Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays.Frontiers in toxicology · 2026Review
- Animal origins free products in cell culture media: a new frontier.Cytotechnology · 2025Review
- A systematic approach towards long-term, serum-free cultivation of fish cells with the RTgill-W1 cell line as example.NAM journal · 2025Article
- Preliminary study on comparison of egg extraction methods for development of fetal bovine serum substitutes in cultured meat.Food chemistry: X · 2024Article
- High level production of stable human serum albumin in Pichia pastoris and characterization of the recombinant product.Bioprocess and biosystems engineering · 2022Article
- Physiological Media in Studies of Cell Metabolism.Molecular biology · 2022Article
- Systems for Muscle Cell Differentiation: From Bioengineering to Future Food.Micromachines · 2021Review
- Development of a modified serum-free medium for Vero cell cultures: effects of protein hydrolysates, l-glutamine and SITE liquid media supplement on cell growth.Cytotechnology · 2021Article
- Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture.International journal of molecular sciences · 2021Review
- Conformational stability as a quality attribute for the cell therapy raw material human serum albumin.RSC advances · 2021Article
- A statistical approach to improve compound screening in cell culture media.Engineering in life sciences · 2019Article
- On-demand serum-free media formulations for human hematopoietic cell expansion using a high dimensional search algorithm.Communications biology · 2019Article
- Adaptation and cultivation of permanent fish cell line CCO in serum-free medium and influence of protein hydrolysates on growth performance.Cytotechnology · 2016Article
- Serum-free medium optimization based on trial design and support vector regression.BioMed research international · 2014Article
- Large-scale production of functional human serum albumin from transgenic rice seeds.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Nonmitogenic survival-enhancing autocrine factors including cyclophilin A contribute to density-dependent mouse embryonic stem cell growth.Stem cell research · 2011Article
- Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.BMC proceedings · 2011Article
- Albumin and mammalian cell culture: implications for biotechnology applications.Cytotechnology · 2010Article
- Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells.Biotechnology journal · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early developments in serum-free media led to a variety of formulations in which components normally provided in serum and required for growth (insulin, transferrin, lipid supplements, trace elements) and poorly defined components (extracts, hydrolysates) were added to defined basal media. These additives were mostly animal-derived. Given recent concerns about TSEs (transmissible spongiform encephalopathies) and other adventitious agents, the drive in media formulations must be towards elimination of animal-origin materials while maintaining cell line productivity. The progress made towards removing animal-derived components and the use of recombinant proteins in serum-free media for mammalian cells is reviewed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.