ArticleIrish journal of medical science2009
Haemochromatosis gene frequency in a control and diabetic Irish population.
Article in Irish journal of medical science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Article
- The landscape of hereditary haemochromatosis risk and diagnosis across the British Isles and Ireland.Nature communications · 2026Article
- Hemochromatosis osteoarthritis.Frontiers in endocrinology · 2026Review
- Screening for Hereditary Hemochromatosis in Newly Referred Diabetes Mellitus.American journal of medicine open · 2023Article
- Twenty-Five Years of Contemplating Genotype-Based Hereditary Hemochromatosis Population Screening.Genes · 2022Review
- Haemochromatosis.Nature reviews. Disease primers · 2018Review
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHereditary haemochromatosis is inherited in an autosomal recessive manner. Two major mutations have been identified and the condition is emerging as one of the most common recessive mutations among subjects of Northern European descendants.
aimThis study investigated the prevalence of C282Y, H63D and S65C (three mutations of clinical significance for haemochromatosis), in a diabetic and control population from the North West of Ireland.
methodsDNA was extracted from whole blood samples of 249 known diabetics and 249 controls and assayed for the three genetic variants (C282Y, H63D and S65C).
resultsThe incidence for C282Y homozygosity is higher in the control population (1 in 83) when compared to the diabetic group (1 in 249). However, this is not statistically significant. S65C heterozygosity occurs with an incidence of 1 in 32 in control individuals and 1 in 124 in the diabetic population. The prevalence of the H63D mutation was similar in both populations.
conclusionFor the three haemochromatosis mutations, there was no significant difference between the control group and the diabetic populations.
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Registered trials
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