ArticleNaunyn-Schmiedeberg's archives of pharmacology2009
Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 55 citations in OpenAlex.
- Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Prokinetic drugs that stimulate 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Mechanisms of systolic heart failure in PP2CxPP5 double transgenic mice.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Contractile effects of dulaglutide in the human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Clozapine acts as an antagonist of human dopamine DNaunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Phosphatase Inhibition Attenuates the Negative Inotropic Effect of Muscarinic Receptors in the Presence of Serotonin.Current issues in molecular biology · 2026Article
- Positive inotropic and chronotropic effects of amisulpride via stimulation of 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Positive inotropic effects of serotonin in atrial EHT: further proof for an atrial phenotype?Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Felcisetrag stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Contractile effects of albiglutide in the human and mouse atrium.Frontiers in endocrinology · 2026Article
- Contractile effects of dexmedetomidine in the human heart.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Tirzepatide increased force of contraction in the isolated human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Bromopride stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Clebopride stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Clozapine is a functional antagonist at cardiac human HNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine.Scientific reports · 2025Article
- Contractile effects of stimulation of DNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Glucagon Can Increase Force of Contraction via Glucagon Receptors in the Isolated Human Atrium.International journal of molecular sciences · 2025Article
- Studies on the mechanisms of action of MR33317.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Tegaserod Stimulates 5-HTInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the mRNA expression and function of 5-hydroxytryptamine (5-HT) receptors as well as their signal transduction in right atrial tissue from patients undergoing cardiac surgery and right ventricular tissue from human donor hearts. In isolated, electrically driven strips from human right atrium, 5-HT exerted concentration-dependent positive inotropic effects (EC(50) value = 0.10 +/- 0.01 microM) and hastened relaxation (positive lusitropic effect). The 5-HT(4) receptor antagonists SB203186 or GR125487 antagonised these effects. 5-HT (2 microM) increased the content of cyclic adenosine monophosphate (cAMP) from 6.86 +/- 1.36 to 19.1 +/- 2.45 pmol/mg protein (n = 6, p < 0.05) but did not alter the tissue content of inositol-1,4,5-trisphosphate (IP(3)). With reverse transcription polymerase chain reaction, mRNAs coding for the 5-HT(4) receptor splice variants 5-HT(4(a)), 5-HT(4(b)) and 5-HT(4(c)) were detected in human right atrium and right ventricle. 5-HT(2A) mRNA only was measurable in human atrium. Expression level of total 5-HT(4) receptor mRNA in the right ventricle amounted to 41% (n = 5-8) of that in the right atrium. 5-HT (2 microM) increased the atrial phosphorylation states of phospholamban to 168% at serine-16 and to 150% at threonine-17 (n = 4; p < 0.05) and of the inhibitory subunit of troponin to 150% (n = 6; p < 0.05). In conclusion, the positive inotropic and lusitropic effects of 5-HT in electrically driven human right atria are mediated via 5-HT(4) receptors. These effects are accompanied by and probably due to an increase in cAMP content and the subsequent elevation of the phosphorylation state of Ca(2+) regulatory proteins.
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