ReviewMolecules (Basel, Switzerland)2008
Polyanionic drugs and viral oncogenesis: a novel approach to control infection, tumor-associated inflammation and angiogenesis.
Review in Molecules (Basel, Switzerland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis.Lipids in health and disease · 2023Article
- Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective.AMB Express · 2023Review
- Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications.Biomedicines · 2021Review
- Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide.JCI insight · 2021Article
- A Bittersweet Computational Journey among Glycosaminoglycans.Biomolecules · 2021Review
- Monoclonal antibody against EV71 3DBMC immunology · 2019Article
- Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity.The Biochemical journal · 2018Article
- Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.Advanced healthcare materials · 2017Article
- Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry.Scientific reports · 2016Article
- Antiviral activity of micafungin against enterovirus 71.Virology journal · 2016Article
- Article
- Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use.Molecules (Basel, Switzerland) · 2015Review
- Article
- Thiocarbamate-linked polysulfonate-peptide conjugates as selective hepatocyte growth factor receptor binders.Bioconjugate chemistry · 2014Article
- Human immunodeficiency virus and heparan sulfate: from attachment to entry inhibition.Frontiers in immunology · 2013Review
- Role of heparan sulfate in sexually transmitted infections.Glycobiology · 2012Review
- Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide.Antimicrobial agents and chemotherapy · 2012Article
- Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation.The Journal of biological chemistry · 2012Article
- Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin.International journal of cardiology · 2011Article
- Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid.The Journal of antimicrobial chemotherapy · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyanionic macromolecules are extremely abundant both in the extracellular environment and inside the cell, where they are readily accessible to many proteins for interactions that play a variety of biological roles. Among polyanions, heparin, heparan sulfate proteoglycans (HSPGs) and glycosphingolipids (GSLs) are widely distributed in biological fluids, at the cell membrane and inside the cell, where they are implicated in several physiological and/or pathological processes such as infectious diseases, angiogenesis and tumor growth. At a molecular level, these processes are mainly mediated by microbial proteins, cytokines and receptors that exert their functions by binding to HSPGs and/or GSLs, suggesting the possibility to use polyanionic antagonists as efficient drugs for the treatment of infectious diseases and cancer. Polysulfated (PS) or polysulfonated (PSN) compounds are a heterogeneous group of natural, semi-synthetic or synthetic molecules whose prototypes are heparin and suramin. Different structural features confer to PS/PSN compounds the capacity to bind and inhibit the biological activities of those same heparin-binding proteins implicated in infectious diseases and cancer. In this review we will discuss the state of the art and the possible future development of polyanionic drugs in the treatment of infectious diseases and cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.