SynthesisJournal of the National Cancer Institute2008
Non-sentinel lymph node metastases associated with isolated breast cancer cells in the sentinel node.
Synthesis in Journal of the National Cancer Institute, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 116 citations in OpenAlex.
- Sentinel node identification rate and nodal involvement in the EORTC 10981-22023 AMAROS trial.Annals of surgical oncology · 2010Trial
- A multi-center retrospective analysis of ultrasound-guided fine needle aspiration biopsy for detecting additional positive axillary node metastasis in early breast cancer.Scientific reports · 2025Article
- Mini Review On: The Roles of DNA Nanomaterials in Phototherapy.International journal of nanomedicine · 2025Review
- Residual Axillary Metastases in Node-Positive Breast Cancer Patients After Neoadjuvant Treatment: A Register-Based Study.Annals of surgical oncology · 2024Article
- Prediction of negative axillary node clearance by sentinel node-positive to total node ratio: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- History and Updates of the GROINSS-V Studies.Cancers · 2022Review
- Verteporfin-Loaded Mesoporous Silica Nanoparticles' Topical Applications Inhibit Mouse Melanoma Lymphangiogenesis and Micrometastasis In Vivo.International journal of molecular sciences · 2021Article
- Should the management of radiation therapy for breast cancer be standardized? Results of a survey on current French practices in breast radiotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2021Review
- The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study.Pathology oncology research : POR · 2020Observational
- Is Low-Volume Disease in the Sentinel Node After Neoadjuvant Chemotherapy an Indication for Axillary Dissection?Annals of surgical oncology · 2018Article
- Sentinel Lymph Node Biopsy in Breast Cancer: A Clinical Review and Update.Journal of breast cancer · 2017Review
- Axillary Micrometastases and Isolated Tumor Cells Are Not an Indication for Post-mastectomy Radiotherapy in Stage 1 and 2 Breast Cancer.Annals of surgical oncology · 2017Article
- Sentinel Lymph Node in Breast Cancer: Review Article from a Pathologist's Point of View.Journal of pathology and translational medicine · 2016Review
- Regional Disease Control in Selected Patients with Sentinel Lymph Node Involvement and Omission of Axillary Lymph Node Dissection.Pathology oncology research : POR · 2015Article
- Patients' choice on axillary lymph node dissection following sentinel lymph node micrometastasis--first report on prospective use of a nomogram in very low risk patients.Pathology oncology research : POR · 2013Article
- Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities.PloS one · 2013Article
- Impact of the american college of surgeons oncology group Z0011 criteria applied to a contemporary patient population.Journal of the American College of Surgeons · 2013Article
- Sentinel lymph node biopsy of the internal mammary chain in breast cancer.Breast cancer research and treatment · 2012Article
- Lymph node metastases and prognosis in penile cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012Article
- The prognostic value of lymph node cross-sectional cancer area in node-positive breast cancer: a comparison with N stage and lymph node ratio.Pathology research international · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are many reports on the frequency of non-sentinel lymph node involvement when isolated tumor cells are found in the sentinel node, but results and recommendations for the use of an axillary lymph node dissection differ among studies. This systematic review was conducted to give an overview of this issue and to provide recommendations for the use of an axillary lymph node dissection in these patients. We searched Medline, Embase, and Cochrane databases from January 1, 2002, through November 27, 2007, for articles on patients with invasive breast cancer who had isolated tumor cells in the sentinel lymph node (according to the sixth edition of the Cancer Staging Manual of the American Joint Committee on Cancer) and who also underwent axillary lymph node dissection. Of 411 selected articles, 29 (including 836 patients) were included in this review. These 29 studies were heterogeneous, reporting a wide range of non-sentinel lymph node involvement (defined as the presence of isolated tumor cells or micro- or macrometastases) associated with isolated tumor cells in the sentinel lymph node, with an overall pooled risk for such involvement of 12.3% (95% confidence interval = 9.5% to 15.7%). This pooled risk estimate was marginally higher than the risk of a false-negative sentinel lymph node biopsy examination (ie, 7%-8%) but marginally lower than the risk of non-sentinel lymph node metastases in patients with micrometastases (ie, approximately 20%) who are currently eligible for an axillary lymph node dissection. Because 36 (64%) of the 56 patients with isolated tumor cells in their sentinel lymph node also had non-sentinel lymph node macrometastases, those patients with isolated tumor cells in the sentinel lymph node without other indications for adjuvant systemic therapy might be candidates for axillary lymph node dissection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.