ArticleAJNR. American journal of neuroradiology2009
Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging.
Article in AJNR. American journal of neuroradiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Cholinesterase inhibitors for mild cognitive impairment.The Cochrane database of systematic reviews · 2012Pooled it
- Brain circuitry, behavior, and cognition: A randomized placebo-controlled trial of donepezil in fragile X syndrome.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Reduced frontal activation during a working memory task in mild cognitive impairment: a non-invasive near-infrared spectroscopy study.CNS neuroscience & therapeutics · 2013Trial
- Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials.Archives of neurology · 2011Trial
- Effects of Combined Intervention of rTMS and Neurotransmitter Drugs on the Brain Functional Networks in Patients with Cognitive Impairment.Brain sciences · 2023Article
- Increased Hippocampal-Inferior Temporal Gyrus White Matter Connectivity following Donepezil Treatment in Patients with Early Alzheimer's Disease: A Diffusion Tensor Probabilistic Tractography Study.Journal of clinical medicine · 2023Article
- Resting-state functional magnetic resonance imaging in a randomized clinical trial for Alzheimer's disease.Neuroimage. Reports · 2021Article
- Change in cognitive function according to cholinesterase inhibitor use and amyloid PET positivity in patients with mild cognitive impairment.Alzheimer's research & therapy · 2021Observational
- Functional MRI technologies in the study of medication treatment effect on Alzheimer's disease.Aging medicine (Milton (N.S.W)) · 2018Review
- Effects of pharmacological and nonpharmacological treatments on brain functional magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment: a critical review.Alzheimer's research & therapy · 2018Review
- Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment during Episodic Memory Encoding.Frontiers in psychiatry · 2013Article
- Anatomical and functional deficits in patients with amnestic mild cognitive impairment.PloS one · 2012Article
- Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI.Journal of magnetic resonance imaging : JMRI · 2011Article
- The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation.Pharmacology, biochemistry, and behavior · 2011Review
- Diagnostic accuracy of the RBANS in mild cognitive impairment: limitations on assessing milder impairments.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2010Article
- Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline.Neurology · 2010Article
- Functional MR imaging and the future of neuroradiology.AJNR. American journal of neuroradiology · 2009Article
- Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study.Dementia and geriatric cognitive disorders extraArticle
- The effect of APOE ε4 allele on cholinesterase inhibitors in patients with Alzheimer disease: evaluation of the feasibility of resting state functional connectivity magnetic resonance imaging.Alzheimer disease and associated disordersArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine the effect of such therapy on the neural substrates underlying memory processing in subjects with MCI by using functional MR imaging (fMRI). MATERIALS AND
methodsThirteen subjects with MCI (mean age, 68 +/- 6.9 years) enrolled in a multicenter double-blind placebo-controlled trial testing the clinical efficacy of the cholinesterase-inhibitor, donepezil, were studied with fMRI at baseline and following 12 or 24 weeks of therapy (single-site pilot study). The cognitive paradigm was delayed-response visual memory for novel faces. Within-group 1-sample t tests were performed on the donepezil and placebo groups at baseline and at follow-up. A repeated-measures analysis of variance design was used to look for a Treatment Group x Time interaction showing a significant donepezil- but not placebo-related change in blood oxygen level-dependent response during the course of the study.
resultsAt baseline, both groups showed multiple areas of activation, including the bilateral dorsolateral prefrontal cortex, fusiform gyrus, and anterior cingulate cortex. On follow-up, the placebo group demonstrated a decreased extent of dorsolateral prefrontal activation, whereas the donepezil group demonstrated an increased extent of activation in the ventrolateral prefrontal cortex. Interaction demonstrated significant donepezil- but not placebo-related change in the left inferior frontal gyrus.
conclusionsDespite the limitations inherent to a pilot study of a small sample, our results point to specific cortical substrates underlying the actions of donepezil, which can be tested in future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.