ArticleThe Journal of clinical endocrinology and metabolism2009
Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Modulation of genetic associations with serum urate levels by body-mass-index in humans.PloS one · 2015Pooled it
- Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.Journal of the American Society of Hypertension : JASH · 2016Trial
- Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.European journal of human genetics : EJHG · 2014Trial
- Proteomic Markers of Dietary Patterns, CKD Progression, and Mortality in the CRIC Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Multifaceted role of inosine in complex diseases and human health.Nutrition reviews · 2025Review
- Elevated blood pressure and hyperuricemia risk: a retrospective cohort study from Wuhu, China.Scientific reports · 2024Article
- Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.Human molecular genetics · 2020Article
- Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Review
- Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane AAtherosclerosis · 2018Article
- Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins.Frontiers in endocrinology · 2018Article
- Association between body mass index and salivary uric acid among Mexican-origin infants, youth and adults: Gender and developmental differences.Developmental psychobiology · 2017Article
- Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner.Antioxidants (Basel, Switzerland) · 2016Article
- GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.BMC genomics · 2016Article
- Causal or Noncausal Relationship of Uric Acid With Diabetes.Diabetes · 2015Article
- Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study.The American journal of clinical nutrition · 2015Article
- Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.Frontiers in genetics · 2013Article
- Serum uric Acid levels in oral cancer patients seen at tertiary institution in Nigeria.Annals of Ibadan postgraduate medicine · 2012Article
- Genome-wide scan identifies a quantitative trait locus at 4p15.3 for serum urate.European journal of human genetics : EJHG · 2010Article
- Heritability of measures of kidney disease among Zuni Indians: the Zuni Kidney Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2010Article
- Sex and age interaction with genetic association of atherogenic uric acid concentrations.Atherosclerosis · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElevated serum uric acid is associated with several cardiovascular disease (CVD) risk factors such as hypertension, inflammation, endothelial dysfunction, insulin resistance, dyslipidemia, and obesity. However, the role of uric acid as an independent risk factor for CVD is not yet clear.
objectiveThe aim of the study was to localize quantitative trait loci regulating variation in serum uric acid and also establish the relationship between serum uric acid and other CVD risk factors in Mexican Americans (n = 848; men = 310, women = 538) participating in the San Antonio Family Heart Study.
methodsQuantitative genetic analysis was conducted using variance components decomposition method, implemented in the software program SOLAR.
resultsMean +/- SD of serum uric acid was 5.35 +/- 1.38 mg/dl. Univariate genetic analysis showed serum uric acid and other CVD risk markers to be significantly heritable (P < 0.005). Bivariate analysis showed significant correlation of serum uric acid with body mass index, waist circumference, waist/hip ratio, total body fat, plasma insulin, serum triglycerides, high-density lipoprotein cholesterol, C-reactive protein, and granulocyte macrophage-colony stimulating factor (P < 0.05). A genome-wide scan for detecting quantitative trait loci regulating serum uric acid variation showed a significant logarithm of odds (LOD) score of 4.72 (empirical LOD score = 4.62; P < 0.00001) on chromosome 3p26. One LOD support interval contains 25 genes, of which an interesting candidate gene is chemokine receptor 2. SUMMARY: There is a significant genetic component in the variation in serum uric acid and evidence of pleiotropy between serum uric acid and other cardiovascular risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.