ArticleThe Journal of biological chemistry2008
Nonmitochondrial ATP/ADP transporters accept phosphate as third substrate.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Diurnal changes of polysome loading track sucrose content in the rosette of wild-type arabidopsis and the starchless pgm mutant.Plant physiology · 2013Pooled it
- 48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis.Nature communications · 2025Article
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- Loss of a pyridoxal-phosphate phosphatase rescues Arabidopsis lacking an endoplasmic reticulum ATP carrier.Plant physiology · 2022Article
- Modified nucleoside triphosphates in bacterial research forRSC chemical biology · 2020Article
- Expansion of the Major Facilitator Superfamily (MFS) to include novel transporters as well as transmembrane-acting enzymes.Biochimica et biophysica acta. Biomembranes · 2020Article
- Identification of Chloroplast Envelope Proteins with Critical Importance for Cold Acclimation.Plant physiology · 2020Article
- Nucleotide Transport and Metabolism in Diatoms.Biomolecules · 2019Review
- Engineering Strategies to Boost Crop Productivity by Cutting Respiratory Carbon Loss.The Plant cell · 2019Review
- Chlamydial Infection From Outside to Inside.Frontiers in microbiology · 2019Review
- ATP compartmentation in plastids and cytosol ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Inhibition of plastid PPase and NTT leads to major changes in starch and tuber formation in potato.Journal of experimental botany · 2018Article
- Purification and functional characterization of the vacuolar malate transporter tDT fromThe Journal of biological chemistry · 2018Article
- Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites.PLoS pathogens · 2014Article
- From endoplasmic reticulum to mitochondria: absence of the Arabidopsis ATP antiporter endoplasmic Reticulum Adenylate Transporter1 perturbs photorespiration.The Plant cell · 2013Article
- Role of metabolite transporters in source-sink carbon allocation.Frontiers in plant science · 2013Article
- Article
- Transport proteins regulate the flux of metabolites and cofactors across the membrane of plant peroxisomes.Frontiers in plant science · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydiales and Rickettsiales as metabolically impaired, intracellular pathogenic bacteria essentially rely on "energy parasitism" by the help of nucleotide transporters (NTTs). Also in plant plastids NTT-type carriers catalyze ATP/ADP exchange to fuel metabolic processes. The uptake of ATP4-, followed by energy consumption and the release of ADP3-, would lead to a metabolically disadvantageous accumulation of negative charges in form of inorganic phosphate (Pi) in the bacterium or organelle if no interacting Pi export system exists. We identified that Pi is a third substrate of several NTT-type ATP/ADP transporters. During adenine nucleotide hetero-exchange, Pi is cotransported with ADP in a one-to-one stoichiometry. Additionally, Pi can be transported in exchange with solely Pi. This Pi homo-exchange depends on the presence of ADP and provides a first indication for only one binding center involved in import and export. Furthermore, analyses of mutant proteins revealed that Pi interacts with the same amino acid residue as the gamma-phosphate of ATP. Import of ATP in exchange with ADP plus Pi is obviously an efficient way to couple energy provision with the export of the two metabolic products (ADP plus Pi) and to maintain cellular phosphate homeostasis in intracellular living "energy parasites" and plant plastids. The additional Pi transport capacity of NTT-type ATP/ADP transporters makes the existence of an interacting Pi exporter dispensable and might explain why a corresponding protein so far has not been identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.