Evidence map›Paper›PMID 19001351›Full record

Trial reportAmerican journal of Alzheimer's disease and other dementias2010

Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment.

Carol F Lippa, Andrea Rosso, Marjorie Hepler, Sigmund Jenssen, Jyoti Pillai, David Irwin

Open access · greenAbstract readClinical Trial, Phase IV
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of Alzheimer's disease and other dementias, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 45 citations in OpenAlex.

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  18. The cognitive impact of antiepileptic drugs.Therapeutic advances in neurological disorders · 2011
    Article
  19. Article
  20. The Role of Epileptic Activity in Alzheimer's Disease.American journal of Alzheimer's disease and other dementias
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carol F LippaDepartment of Neurology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA. clippa@drexelmed.edu
Andrea Rosso
Marjorie Hepler
Sigmund Jenssen
Jyoti Pillai
David Irwin
Drexel University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment and seizures are common in our aging population. Anticonvulsant treatment is problematic due to sedation, cognitive slowing, and behavioral changes. Levetiracetam has favorable pharmacokinetics, good efficacy in elderly individuals, a favorable side effect profile, and lacks major drug interactions. We conducted a prospective, uncontrolled, phase 4, open label, 12-week study of levetiracetam to better profile its efficacy, safety, and impact on cognitive/behavioral status in 24 cognitively impaired, elderly individuals. In total, 69% were seizure free for the duration of the study; the remaining participants had satisfactory seizure control. Fatigue was the most common side effect (5 participants). Significant overall improvements were observed for the Folstein's Mini-Mental State Examination and the Alzheimer's Disease Assessment Scale-Cognitive. No significant changes were seen in behavioral or functional measures. Levetiracetam is an effective antiepileptic drug in elderly individuals with cognitive impairment. At 3 months, participants who remained on levetiracetam showed excellent cognitive tolerability.

Indexed as

AgedAged, 80 and overAgingAnticonvulsantsCognitionCognition DisordersDisease-Free SurvivalFatigueFemaleHumansLevetiracetamMaleMiddle AgedPiracetamProspective StudiesPsychiatric Status Rating ScalesAnticonvulsantsLevetiracetamPiracetam

Identifiers

PMID19001351
PMCPMC10845688
OpenAlexW2052712624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.