ArticleGenetics2009
High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- Extracellular vesicles aid in the transfer of long-term associative memory betweenbioRxiv : the preprint server for biology · 2025Article
- Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes.PLoS genetics · 2023Article
- Genetic diversity estimates for themicroPublication biology · 2022Article
- Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei.G3 (Bethesda, Md.) · 2021Article
- Chromosome-Level Assembly of theGenetics · 2020Article
- Intrinsic differences between males and females determine sex-specific consequences of inbreeding.BMC evolutionary biology · 2016Article
- Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes.BMC evolutionary biology · 2015Article
- Article
- Sex, age, and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor expression.Current biology : CB · 2014Article
- Microevolution of nematode miRNAs reveals diverse modes of selection.Genome biology and evolution · 2014Article
- Rapid evolution of phenotypic plasticity and shifting thresholds of genetic assimilation in the nematode Caenorhabditis remanei.G3 (Bethesda, Md.) · 2014Article
- A recent global selective sweep on the age-1 phosphatidylinositol 3-OH kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei.G3 (Bethesda, Md.) · 2014Article
- Molecular hyperdiversity and evolution in very large populations.Molecular ecology · 2013Article
- Fine-scale signatures of molecular evolution reconcile models of indel-associated mutation.Genome biology and evolution · 2013Article
- Global population genetic structure of Caenorhabditis remanei reveals incipient speciation.Genetics · 2012Article
- Causes and consequences of the evolution of reproductive mode in Caenorhabditis nematodes.Trends in genetics : TIG · 2012Review
- Investigating the Relationship between Topology and Evolution in a Dynamic Nematode Odor Genetic Network.International journal of evolutionary biology · 2012Article
- MicroRNA sequence variation potentially contributes to within-species functional divergence in the nematode Caenorhabditis briggsae.Genetics · 2011Article
- Shifting patterns of natural variation in the nuclear genome of caenorhabditis elegans.BMC evolutionary biology · 2011Article
Corrections and comments
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4 authors.
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Abstract
Almost all organismal function is controlled by pathways composed of interacting genetic components. The relationship between pathway structure and the evolution of individual pathway components is not completely understood. For the nematode Caenorhabditis elegans, chemosensory pathways regulate critical aspects of an individual's life history and development. To help understand how olfaction evolves in Caenorhabditis and to examine patterns of gene evolution within transduction pathways in general, we analyzed nucleotide variation within and between species across two well-characterized olfactory pathways, including regulatory genes controlling the fate of the cells in which the pathways are expressed. In agreement with previous studies, we found much higher levels of polymorphism within C. remanei than within the related species C. elegans and C. briggsae. There are significant differences in the rates of nucleotide evolution for genes across the two pathways but no particular association between evolutionary rate and gene position, suggesting that the evolution of functional pathways must be considered within the context of broader gene network structure. However, developmental regulatory genes show both higher levels of divergence and polymorphism than the structural genes of the pathway. These results show that, contrary to the emerging paradigm in the evolution of development, important structural changes can accumulate in transcription factors.
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