ArticlePediatrics2008
Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons.
Article in Pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Superior mesenteric artery blood flow velocities following medical treatment of a patent ductus arteriosus.The Journal of pediatrics · 2014Trial
- Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus.The Journal of pediatrics · 2013Trial
- Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026Review
- Clinical Impact of the PDA and Its Management on Outcomes of Preterm Infants with NEC: A Review.American journal of perinatology · 2026Review
- Characteristics of neonatal necrotizing enterocolitis in relation to the presence or absence of patent ductus arteriosus.BMC pregnancy and childbirth · 2025Article
- Should we "eliminate" PDA shunt in preterm infants? A narrative review.Frontiers in pediatrics · 2024Review
- Article
- Combination pharmacotherapy for patent ductus arteriosus: Rationale and evidence.Seminars in perinatology · 2023Review
- Measuring gut perfusion and blood flow in neonates using ultrasound Doppler of the superior mesenteric artery: a narrative review.Frontiers in pediatrics · 2023Review
- The effect of prolonged tracheal intubation on the association between patent ductus arteriosus and bronchopulmonary dysplasia (grades 2 and 3).Journal of perinatology : official journal of the California Perinatal Association · 2020Observational
- Review
- Circulatory Insufficiency and Hypotension Related to the Ductus Arteriosus in Neonates.Frontiers in pediatrics · 2018Review
- Enteral feeding during indomethacin treatment for patent ductus arteriosus: association with gastrointestinal outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle.The Journal of endocrinology · 2014Article
- Hyperglycemia increases the risk of death in extremely preterm baboons.Pediatric research · 2013Article
- Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation?Pediatric cardiology · 2012Article
- Learning to live with patency of the ductus arteriosus in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2011Review
- Spectral Doppler waveforms in systemic arteries and physiological significance of a patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2011Article
- Patent ductus arteriosus in the preterm infant: to treat or not to treat?Journal of perinatology : official journal of the California Perinatal Association · 2010Review
- Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency.Pediatric research · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSuperior mesenteric artery flow increases after a feeding to meet the intestines' increased metabolic demands. Although a patent ductus arteriosus can affect superior mesenteric artery perfusion in nonfeeding infants, there is no information about its effects on the hyperemic response that follows a feeding.
objectiveOur goal was to study the effects of a patent ductus arteriosus on superior mesenteric artery perfusion in preterm baboons.
designPreterm baboons were delivered at 67% gestation and ventilated for 14 days. Enteral feedings were begun and advanced per protocol. Feeding studies were performed between days 10 and 14. Thirty-one studies were performed in animals with a closed ductus; 21 studies in those with a moderate patent ductus arteriosus shunt (pulmonary-to-systemic blood flow ratio>or=2:1). Two-dimensional echocardiographic and Doppler examinations were performed before and 10 and 30 minutes after a feeding. The groups were similar in birth weights, feeding volumes, and age at time of study.
resultsDuring the preprandial period, baboons with a moderate patent ductus arteriosus had significantly lower blood pressures and systemic blood flows than animals with a closed ductus. Preprandial superior mesenteric artery-blood flow velocities did not differ between the open and closed ductus groups. Animals with a closed ductus increased their superior mesenteric artery-velocities (diastolic and mean) and decreased their superior mesenteric artery relative-vascular-resistance (mean blood pressure/mean superior mesenteric artery-velocity) by 10 minutes after the feeding. By 30 minutes after the feeding, the values were returning to their preprandial values. In contrast, in baboons in the patent ductus arteriosus group, there were no significant changes in superior mesenteric artery-velocity or resistance after the feeding, and superior mesenteric artery-velocities were significantly lower than those in the closed ductus group.
conclusionsA moderate patent ductus arteriosus shunt limits the ability of the preterm newborn baboon to increase its postprandial mesenteric blood flow velocity. We speculate that this may interfere with its ability to meet increased intestinal metabolic demands and may contribute to feeding difficulties.
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