ArticleThorax2009
Genome-wide transcriptional profiling linked to social class in asthma.
Article in Thorax, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Pooled it
- Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.Scientific reports · 2016Trial
- Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.Psychoneuroendocrinology · 2016Trial
- Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial.Psychoneuroendocrinology · 2013Trial
- Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.Biological psychiatry · 2012Trial
- Article
- Pathways to maternal health inequities: Structural racism, sleep, and physiological stress.Brain, behavior, and immunity · 2025Review
- Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathways.Mucosal immunology · 2024Article
- The health risk of social disadvantage is transplantable into a new host.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Omega-3 Polyunsaturated Fatty Acid Levels in Maternal and Cord Plasma Are Associated with Maternal Socioeconomic Status.Nutrients · 2023Article
- Ozone Pollution, Perceived Support at Home, and Asthma Symptom Severity in the Adolescent Sample of the California Health Interview Survey.International journal of behavioral medicine · 2023Article
- Human social genomics: Concepts, mechanisms, and implications for health.Lifestyle medicine (Hoboken, N.J.) · 2023Article
- Why is subjective stress severity a stronger predictor of health than stressor exposure? A preregistered two-study test of two hypotheses.Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction.Frontiers in psychiatry · 2023Article
- Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model.Head & neck · 2022Article
- What Are the Health Consequences of Upward Mobility?Annual review of psychology · 2022Article
- A biopsychosocial framework for understanding sexual and gender minority health: A call for action.Neuroscience and biobehavioral reviews · 2021Review
- Article
- Psychosocial experiences modulate asthma-associated genes through gene-environment interactions.eLife · 2021Article
- Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control.Scientific reports · 2021Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesLow socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. This study tested whether the social environment could get "under the skin" to alter genomic activity in children with asthma. DESIGN AND
participantsTwo group design of children with physician diagnosed asthma who came from low or high SES families. OUTCOMES: Genome-wide transcriptional profiles from T lymphocytes of children with asthma.
resultsChildren with asthma from a low SES background showed overexpression of genes regulating inflammatory processes, including those involved in chemokine activity, stress responses and wound responses, compared with children with asthma from a high SES background. Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y and increased nuclear factor kappaB transcriptional signalling mediated these effects. These pathways are known to regulate catecholamine and inflammatory signalling in immune cells.
conclusionsThis study provides the first evidence in a sample of paediatric patients diagnosed with asthma that the larger social environment can affect processes at the genomic level. Specifically, gene transcription control pathways that regulate inflammation and catecholamine signalling were found to vary by SES in children with asthma. Because these pathways are the primary targets of many asthma medications, these findings suggest that the larger social environment may alter molecular mechanisms that have implications for the efficacy of asthma therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.