ArticleDevelopmental cell2008
Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.
Article in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning fromInternational journal of molecular sciences · 2022Review
- Article
- Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.Journal of developmental biology · 2021Review
- Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.Cell reports · 2019Article
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System.Journal of molecular biology · 2017Article
- Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning.Developmental biology · 2016Article
- Genome-Wide Approaches to Drosophila Heart Development.Journal of cardiovascular development and disease · 2016Article
- The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.Epigenetics & chromatin · 2016Article
- Differentiated muscles are mandatory for gas-filling of the Drosophila airway system.Biology open · 2015Article
- Outside-in signaling--a brief review of GPCR signaling with a focus on the Drosophila GPCR family.Journal of cell science · 2015Review
- Cellular Mechanisms of Drosophila Heart Morphogenesis.Journal of cardiovascular development and disease · 2015Article
- In-depth proteomics characterization of embryogenesis of the honey bee worker (Apis mellifera ligustica).Molecular & cellular proteomics : MCP · 2014Article
- Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila.BMC developmental biology · 2014Article
- ROS regulate cardiac function via a distinct paracrine mechanism.Cell reports · 2014Article
- Article
- The conserved ADAMTS-like protein lonely heart mediates matrix formation and cardiac tissue integrity.PLoS genetics · 2013Article
- JAK/Stat signaling regulates heart precursor diversification in Drosophila.Development (Cambridge, England) · 2011Article
- Drosophila, genetic screens, and cardiac function.Circulation research · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The gene networks regulating heart morphology and cardiac integrity are largely unknown. We previously reported a role for the heterotrimeric G protein gamma subunit 1 (Ggamma1) in mediating cardial-pericardial cell adhesion in Drosophila. Here we show G-oalpha47A and Gbeta13F cooperate with Ggamma1 to maintain cardiac integrity. Cardial-pericardial cell adhesion also relies on the septate junction (SJ) proteins Neurexin-IV (Nrx-IV), Sinuous, Coracle, and Nervana2, which together function in a common pathway with Ggamma1. Furthermore, Ggamma1 signaling is required for proper SJ protein localization, and loss of at least one SJ protein, Nrx-IV, induces cardiac lumen collapse. These results are surprising because the embryonic heart lacks SJs and suggest that SJ proteins perform noncanonical functions to maintain cardiac integrity in Drosophila. Our findings unveil the components of a previously unrecognized network of genes that couple G protein signaling with structural constituents of the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.