ArticleThe Journal of experimental medicine1991
Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.
Article in The Journal of experimental medicine, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Distinct autoreactive CD19Nature communications · 2025Article
- T cell help in the autoreactive germinal center.Scandinavian journal of immunology · 2022Review
- Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.Molecular cancer · 2022Article
- Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1Scientific reports · 2017Article
- mTOR has distinct functions in generating versus sustaining humoral immunity.The Journal of clinical investigation · 2016Article
- Follicular helper T cell in immunity and autoimmunity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Review
- Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Follicular helper T cells: new insights into mechanisms of autoimmune diseases.Ochsner journal · 2013Article
- B cell tolerance and positive selection in lupus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Dysregulation of germinal centres in autoimmune disease.Nature reviews. Immunology · 2009Review
- Follicular helper T cells are required for systemic autoimmunity.The Journal of experimental medicine · 2009Article
- Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.European journal of immunology · 2000Article
- The promotion of V region hypermutation.The Journal of experimental medicine · 1997Article
- Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.The EMBO journal · 1996Article
- Mutational analysis of an autoantibody: differential binding and pathogenicity.The Journal of experimental medicine · 1994Article
- Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 1994Article
- Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies.Immunologic research · 1994Article
- Lack of connectivity between the induced and autoimmune repertoires of lpr/lpr mice.Immunology · 1993Article
- Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.The Journal of experimental medicine · 1992Article
- Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding.The EMBO journal · 1992Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have studied 19 S107 heavy chain variable region gene (VH11)-encoded monoclonal antibodies from NZBWF1 mice. These studies show that a single VH gene can encode both antibodies to foreign antigens (anti-phosphorylcholine) and to self antigens (anti-double-stranded DNA) in the same animal. All of the anti-DNA antibodies contain many somatic mutations compared with the relevant germline genes. Since the anti-DNA antibodies were extensively somatically mutated and had undergone isotype switching, the response seems to be T cell dependent. While some of the antibodies appear to be the products of an antigen-driven and antigen-selected response, a number of characteristics of the antibodies suggest that forces other than antigen are contributing to the stimulation and selection of this response.
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