ArticleStructure (London, England : 1993)2008
Genome pool strategy for structural coverage of protein families.
Article in Structure (London, England : 1993), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Phosphoarginine modulates oligomerization and repressor activity of mycobacterial ClpC2.bioRxiv : the preprint server for biology · 2026Article
- Insights into the Structure of Rubisco from Dinoflagellates-In Silico Studies.International journal of molecular sciences · 2021Article
- The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Is unphosphorylated Rex, as multifunctional protein of HTLV-1, a fully intrinsically disordered protein? An in silico study.Biochemistry and biophysics reports · 2016Article
- Increasing the structural coverage of tuberculosis drug targets.Tuberculosis (Edinburgh, Scotland) · 2015Article
- Improving the chances of successful protein structure determination with a random forest classifier.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Correlation between protein sequence similarity and crystallization reagents in the biological macromolecule crystallization database.International journal of molecular sciences · 2012Article
- An approach to crystallizing proteins by metal-mediated synthetic symmetrization.Protein science : a publication of the Protein Society · 2011Article
- Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima.Protein science : a publication of the Protein Society · 2011Article
- The JCSG high-throughput structural biology pipeline.Acta crystallographica. Section F, Structural biology and crystallization communications · 2010Article
- Prediction of protein crystallization outcome using a hybrid method.Journal of structural biology · 2010Article
- Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.Nucleic acids research · 2009Article
- Structural genomics target selection for the New York consortium on membrane protein structure.Journal of structural and functional genomics · 2009Article
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7 authors.
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Abstract
Even closely homologous proteins often have different crystallization properties and propensities. This observation can be used to introduce an additional dimension into crystallization trials by simultaneous targeting multiple homologs in what we call a "genome pool" strategy. We show that this strategy works because protein physicochemical properties correlated with crystallization success have a surprisingly broad distribution within most protein families. There are also "easy" and "difficult" families where this distribution is tilted in one direction. This leads to uneven structural coverage of protein families, with more "easy" ones solved. Increasing the size of the "genome pool" can improve chances of solving the "difficult" ones. In contrast, our analysis does not indicate that any specific genomes are "easy" or "difficult". Finally, we show that the group of proteins with known 3D structures is systematically different from the general pool of known proteins and we assess the structural consequences of these differences.
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