ArticleVirus research2009
Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate.
Article in Virus research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Machine Learning Prediction of Adenovirus D8 Conjunctivitis Complications from Viral Whole-Genome Sequence.Ophthalmology science · 2022Article
- Review
- Adenovirus and the Cornea: More Than Meets the Eye.Viruses · 2021Review
- Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis.Progress in retinal and eye research · 2020Review
- Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D.FEBS letters · 2019Review
- An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China.BMC infectious diseases · 2019Article
- Temporal dynamics of Human mastadenovirus species in cases of respiratory illness in southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013.BMC infectious diseases · 2018Article
- Adenoviromics: Mining the Human Adenovirus Species D Genome.Frontiers in microbiology · 2018Review
- Molecular phylogeny of a novel human adenovirus type 8 strain causing a prolonged, multi-state keratoconjunctivitis epidemic in Germany.Scientific reports · 2017Article
- Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69.Virology · 2015Article
- Ultrastructure of adenovirus keratitis.Investigative ophthalmology & visual science · 2015Article
- Article
- A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation.PLoS pathogens · 2013Article
- Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64.Investigative ophthalmology & visual science · 2012Article
- Overreliance on the hexon gene, leading to misclassification of human adenoviruses.Journal of virology · 2012Article
- Article
- The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis.Virus research · 2011Article
- Molecular evolution of human species D adenoviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality.Virology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Human adenovirus type 19 (HAdV-19) is a major etiologic agent of epidemic keratoconjunctivitis (EKC), a common and severe eye infection associated with long-term visual morbidity due to persistent corneal inflammation. Ironically, while the prototype strain of HAdV-19 does not cause eye infections, other isolates of the serotype have caused major outbreaks of EKC. Here we have sequenced a clinical isolate of HAdV-19 (HAdV-19 strain C) from a human patient with EKC. Global pairwise alignment of HAdV-19C to other HAdV species D serotypes identified areas of sequence divergence in the penton base (host cell internalization signal), hexon (principal viral capsid structural protein), E3 (site of immunomodulatory genes), and fiber (host cell-binding ligand) regions. Comparison of HAdV-19 strain C to the recently sequenced HAdV-37, another EKC causing serotype, identified sequence diversity in the penton base and hexon, but sequence conservation in the E3 and fiber regions. Elucidation of the HAdV-19C genome will facilitate future studies into the pathogenesis of EKC, and may shed light on the genetic determinants of corneal tropism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.