ArticleExperimental eye research2009
Transscleral iontophoretic and intravitreal delivery of a macromolecule: study of ocular distribution in vivo and postmortem with MRI.
Article in Experimental eye research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Non-Invasive Iontophoretic Delivery of Cytochrome c to the Posterior Segment and Determination of Its Ocular Biodistribution.Pharmaceutics · 2022Article
- In Vivo Experimental and Analytical Studies for Bevacizumab Diffusion Coefficient Measurement in the Rabbit Vitreous Humor.Journal of heat transfer · 2021Article
- Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin.Pharmaceutics · 2020Article
- Transscleral Iontophoresis for Noninvasive Ocular Drug Delivery of Macromolecules.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2020Article
- Ocular Biodistribution Studies using Molecular Imaging.Pharmaceutics · 2019Review
- Diffusive Transport in the Vitreous Humor: Experimental and Analytical Studies.Journal of heat transfer · 2019Review
- Contact Lens Based Drug Delivery to the Posterior Segment Via Iontophoresis in Cadaver Rabbit Eyes.Pharmaceutical research · 2019Article
- Mass diffusion coefficient measurement for vitreous humor using FEM and MRI.IOP conference series. Materials science and engineering · 2018Article
- Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides.Nucleic acid therapeutics · 2017Article
- Long-acting protein drugs for the treatment of ocular diseases.Nature communications · 2017Article
- Hydrodynamic Radii of Ranibizumab, Aflibercept and Bevacizumab Measured by Time-Resolved Phosphorescence Anisotropy.Pharmaceutical research · 2016Article
- One-Year Feasibility Study of Replenish MicroPump for Intravitreal Drug Delivery: A Pilot Study.Translational vision science & technology · 2014Article
- Impact of repeated topical-loaded manganese-enhanced MRI on the mouse visual system.Investigative ophthalmology & visual science · 2012Article
- MRI study of subconjunctival and intravitreal injections.Journal of pharmaceutical sciences · 2012Article
- Ocular pharmacokinetic study using T₁ mapping and Gd-chelate- labeled polymers.Pharmaceutical research · 2011Article
- Noninvasive topical loading for manganese-enhanced MRI of the mouse visual system.Investigative ophthalmology & visual science · 2011Article
- Non-contact measurement of linear external dimensions of the mouse eye.Journal of neuroscience methods · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The distribution and clearance of macromolecules in ocular delivery are not well understood. It has been hypothesized that iontophoresis can enhance transscleral delivery of macromolecules. The objective of this study was to investigate the ocular distribution of a macromolecule after transscleral iontophoretic delivery and intravitreal injection in vivo using nuclear magnetic resonance imaging (MRI) and to compare these results. Experiments of constant current transscleral iontophoresis of 4mA or intravitreal injection were performed on New Zealand white rabbits in vivo. Iontophoresis experiments were also performed on rabbits postmortem. Galbumin (Gd-labeled albumin) was the model permeant surrogate to clinical therapeutic agents. MRI was used to monitor the distribution of the molecule in the eye after ocular iontophoresis and intravitreal injection. In addition, the conjunctiva, sclera, choroid, and retina were extracted in the transscleral iontophoresis study to determine the amounts of Galbumin in these tissues using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The results show that iontophoresis enhanced the ocular delivery of Galbumin. The macromolecule was mainly delivered into the conjunctiva and sclera in microgram quantities and then diffused towards the posterior section in the upper hemisphere of the eye in vivo. Both in vivo and postmortem studies show that the iontophoretic delivery of Galbumin into the vitreous was below the detection limit. In the intravitreal injection study, the diffusion coefficient of Galbumin in the vitreous humor was estimated to be close to that of free aqueous diffusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.