ArticleBMC evolutionary biology2008
Chromosomal plasticity and evolutionary potential in the malaria vector Anopheles gambiae sensu stricto: insights from three decades of rare paracentric inversions.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Article
- Chromosomal rearrangements in mosquitoes: from micro- to macroevolution.Current opinion in insect science · 2025Review
- Defining the genetics of the widely used G3 strain of the mosquito, Anopheles gambiae.Scientific reports · 2025Article
- Population genomic evidence of a putative 'far-west' African cryptic taxon in the Anopheles gambiae complex.Communications biology · 2024Article
- Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe,Insects · 2024Article
- Speciation within theResearch square · 2024Article
- A novel tetra-primer ARMS-PCR approach for the molecular karyotyping of chromosomal inversion 2Ru in the main malaria vectors Anopheles gambiae and Anopheles coluzzii.Parasites & vectors · 2023Article
- Novel genotyping approaches to easily detect genomic admixture between the major Afrotropical malaria vector species, Anopheles coluzzii and An. gambiae.Molecular ecology resources · 2021Article
- Inversion Genotyping in theG3 (Bethesda, Md.) · 2020Article
- Article
- A new species in the major malaria vector complex sheds light on reticulated species evolution.Scientific reports · 2019Article
- In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in theG3 (Bethesda, Md.) · 2019Article
- A chromosome-scale assembly of the major African malaria vector Anopheles funestus.GigaScience · 2019Article
- Association mapping desiccation resistance within chromosomal inversions in the African malaria vector Anopheles gambiae.Molecular ecology · 2019Article
- Inversions are bigger on the X chromosome.Molecular ecology · 2019Article
- Unexpectedly high Plasmodium sporozoite rate associated with low human blood index in Anopheles coluzzii from a LLIN-protected village in Burkina Faso.Scientific reports · 2018Article
- Phylogenetic signal from rearrangements in 18 Anopheles species by joint scaffolding extant and ancestral genomes.BMC genomics · 2018Article
- Mitochondrial genomes ofF1000Research · 2018Article
- The Physical Genome Mapping of Anopheles albimanus Corrected Scaffold Misassemblies and Identified Interarm Rearrangements in Genus Anopheles.G3 (Bethesda, Md.) · 2017Article
- Chromosomal inversions and ecotypic differentiation in Anopheles gambiae: the perspective from whole-genome sequencing.Molecular ecology · 2016Article
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Abstract
backgroundIn the Anopheles gambiae complex, paracentric chromosomal inversions are non-randomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on chromosome arm 2R, which represents only approximately 30% of the complement. Moreover, in An. gambiae sensu stricto, 6/7 common polymorphic inversions occur on 2R. Most of these inversions are considered markers of ecological adaptation that increase the fitness of the carriers of alternative karyotypes in contrasting habitats. However, little is known about the evolutionary forces responsible for their origin and subsequent establishment in field populations.
resultsHere, we present data on 82 previously undescribed rare chromosomal inversions (RCIs) recorded during extensive field sampling in 16 African countries over a 30 year period, which may shed light on the dynamics of chromosomal plasticity in An. gambiae. We analyzed breakpoint distribution, length, and geographic distribution of RCIs, and compared these measures to those of the common inversions. We found that RCIs, like common inversions, are disproportionately clustered on 2R, which may indicate that this arm is especially prone to breakages. However, contrasting patterns were observed between the geographic distribution of common inversions and RCIs. RCIs were equally frequent across biomes and on both sides of the Great Rift Valley (GRV), whereas common inversions predominated in arid ecological settings and west of the GRV. Moreover, the distribution of RCI lengths followed a random pattern while common inversions were significantly less frequent at shorter lengths.
conclusionBecause 17/82 (21%) RCIs were found repeatedly at very low frequencies - at the same sampling location in different years and/or in different sampling locations - we suggest that RCIs are subject mainly to drift under unperturbed ecological conditions. Nevertheless, RCIs may represent an important reservoir of genetic variation for An. gambiae in response to environmental changes, further testifying to the considerable evolutionary potential hidden within this pan-African malaria vector.
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