ArticleProceedings of the National Academy of Sciences of the United States of America1991
Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells.Scientific reports · 2021Article
- Myofibroblast Adhesome Analysis by Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation.Cell reports · 2020Article
- Regulation of IL-1 signaling through control of focal adhesion assembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- IL-1β enhances cell adhesion to degraded fibronectin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Contribution of orthodontic load to inflammation-mediated periodontal destruction.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2010Article
- TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.The Journal of biological chemistry · 2010Article
- The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium.Endocrinology · 2008Article
- The IL-1 receptor and Rho directly associate to drive cell activation in inflammation.The Journal of clinical investigation · 1999Article
- Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin.Molecular biology of the cell · 1998Article
- Regulation of interleukin 1 signalling through integrin binding and actin reorganization: disparate effects on NF-kappaB and stress kinase pathways.The Biochemical journal · 1998Article
- Interleukin 1-induced calcium signalling in chondrocytes requires focal adhesions.The Biochemical journal · 1997Article
- Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.Molecular biology of the cell · 1996Article
- Vinculin, talin and focal adhesions.Journal of muscle research and cell motility · 1996Review
- Specific activation of beta-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor.The Biochemical journal · 1994Article
- Signal transduction by tumor necrosis factor mediated by JNK protein kinases.Molecular and cellular biology · 1994Article
- Macrophage activation and muscle remodeling at myotendinous junctions after modifications in muscle loading.The American journal of pathology · 1994Article
- Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells.The Journal of clinical investigation · 1994Article
- Interleukin-1 beta regulation of fibroblast proteoglycan synthesis involves a decrease in versican steady-state mRNA levels.The Biochemical journal · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The majority of interleukin 1 (IL-1) receptors in human fibroblasts has been shown to be localized at focal adhesions. This study describes rapid alterations caused by IL-1 beta/IL-1-receptor interaction at these sites. Fibroblast monolayers, incubated with IL-1 beta and prepared for electron microscopy, showed successive loss of cell-substratum contact and fewer and less-pronounced processes. Immunocytochemistry revealed loss and redistribution of the talin staining initially observed after 5-15 min of IL-1 beta incubation. Similarly, the cytoskeleton showed a decrease in staining and a disorganization starting from 15 to 30 min after IL-1 addition, whereas extracellular fibronectin appeared largely unaffected. Prelabeling with [32P]phosphate showed a 2- to 3-fold increase in the level of talin phosphorylation, peaking at 15 min. Phospho amino acid analyses revealed a higher level of serine and threonine phosphorylation. The data suggest that the action of IL-1 beta on fibroblasts may be partially mediated by direct phosphorylation of talin via activation of a protein serine/threonine kinase, leading to changes in transmembrane linkage proteins and the cytoskeleton. Such alterations at focal adhesions may provide a mechanism by which IL-1 can rapidly modulate cell-matrix interactions during inflammation and wound healing.
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