ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2008
Supporting the design of translational clinical studies through the generation and verification of conceptual knowledge-anchored hypotheses.
Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Enabling online studies of conceptual relationships between medical terms: developing an efficient web platform.JMIR medical informatics · 2014Article
- Formalizing an integrative, multidisciplinary cancer therapy discovery workflow.Cancer research · 2013Article
- Article
- k-Neighborhood decentralization: a comprehensive solution to index the UMLS for large scale knowledge discovery.Journal of biomedical informatics · 2012Article
- Chapter 1: Biomedical knowledge integration.PLoS computational biology · 2012Article
- The TOKEn project: knowledge synthesis for in silico science.Journal of the American Medical Informatics Association : JAMIA · 2011Article
- The TRITON Project: Design and Implementation of an Integrative Translational Research Information Management Platform.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2010Article
- Multi-dimensional discovery of biomarker and phenotype complexes.BMC bioinformatics · 2010Article
- Targeted Therapy Database (TTD): a model to match patient's molecular profile with current knowledge on cancer biology.PloS one · 2010Article
- Translational research queries, fascia research congress sequels, and beyond....International journal of therapeutic massage & bodywork · 2010Article
- Evaluating the impact of conceptual knowledge engineering on the design and usability of a clinical and translational science collaboration portal.Summit on translational bioinformatics · 2010Article
- Translational informatics: enabling high-throughput research paradigms.Physiological genomics · 2009Review
- Conceptual dissonance: evaluating the efficacy of natural language processing techniques for validating translational knowledge constructs.Summit on translational bioinformatics · 2009Article
- Applying knowledge-anchored hypothesis discovery methods to advance clinical and translational research: the OAMiner project.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The ability to generate hypotheses based upon the contents of large-scale, heterogeneous data sets is critical to the design of translational clinical studies. In previous reports, we have described the application of a conceptual knowledge engineering technique, known as constructive induction (CI) in order to satisfy such needs. However, one of the major limitations of this method is the need to engage multiple subject matter experts to verify potential hypotheses generated using CI. In this manuscript, we describe an alternative verification technique that leverages published biomedical literature abstracts. Our report will be framed in the context of an ongoing project to generate hypotheses related to the contents of a translational research data repository maintained by the CLL Research Consortium. Such hypotheses will are intended to inform the design of prospective clinical studies that can elucidate the relationships that may exist between biomarkers and patient phenotypes.
Indexed as
Identifiers
18998958PMC2656058What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.