ReviewDocumenta ophthalmologica. Advances in ophthalmology2009
Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniques.
Review in Documenta ophthalmologica. Advances in ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Experimental models to study oxidative stress in glaucoma: integratingFrontiers in pharmacology · 2026Review
- Longitudinal retinal functional evaluation using full-field electroretinography in New Zealand white and Dutch Belted rabbits with aging.Scientific reports · 2025Article
- Review: Neuroprotective Nanocarriers in Glaucoma.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Epithelial Membrane Protein 2 (EMP2) Blockade Attenuates Pathological Neovascularization in Murine Oxygen-Induced Retinopathy.Investigative ophthalmology & visual science · 2024Article
- Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation.Pharmaceutics · 2023Article
- Electroretinogram (ERG) to Evaluate the Retina Using Mouse Models.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Sex-related differences in retinal function in Wistar rats: implications for toxicity and safety studies.Frontiers in toxicology · 2023Article
- PnPP-19 Peptide as a Novel Drug Candidate for Topical Glaucoma Therapy Through Nitric Oxide Release.Translational vision science & technology · 2020Article
- Induction of retinopathy by fibrillar oxalate assemblies.Communications chemistry · 2020Article
- Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans-A Review of the Literature.Medicina (Kaunas, Lithuania) · 2019Review
- Retinal alterations in a pre-clinical model of an autism spectrum disorder.Molecular autism · 2019Article
- Intravitreal Trimethoprim and Sulfamethoxazole Toxicity to the Retina of Albino Rabbits.Translational vision science & technology · 2018Article
- Retinal Toxicity of Intravitreal Injection of Ziv-Aflibercept in Albino Rabbits.Translational vision science & technology · 2018Article
- Comparison between albino and pigmented rabbit ERGs.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Infliximab exerts a dose-dependent effect on retinal safety in the albino rabbit.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Safety of intravitreal clindamycin in albino rabbit eyes.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Test-retest reliability of scotopic full-field electroretinograms in rabbits.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Glutamate and hypoxia as a stress model for the isolated perfused vertebrate retina.Journal of visualized experiments : JoVE · 2015Article
- PACAP application improves functional outcome of chronic retinal ischemic injury in rats-evidence from electroretinographic measurements.Journal of molecular neuroscience : MN · 2014Article
- Retinal function and morphology in the rabbit eye after intravitreal injection of the TNF alpha inhibitor adalimumab.Current eye research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drugs are frequently tested for retinal toxicity in animal models in order to address applied and basic research questions. When a retinal toxicity study is designed, the researcher needs to consider several factors depending on his/her research questions. Among the factors that need to be addressed before a toxicity study is conducted are: the animal species to be used, choice of experimental (functional and/or morphological) techniques, procedure of testing, period of follow-up, and modes of data analysis. This review is a summary of 20 years' experience of studying retinal toxicity of different drugs in rabbits and rats. The use of the electroretinogram and the visual evoked potential for assessment of outer and inner retinal function, respectively, is described as well as the use of morphological techniques (histology, histochemistry, and immunocytochemistry). The advantages and limitations of functional and morphological techniques are discussed with specific examples from my experience. Recommendations for future drug toxicity studies are summarized.
Indexed as
Identifiers
18998183What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.