ArticlePflugers Archiv : European journal of physiology2009
Ether-à-gogo-related gene (erg1) potassium channels shape the dark response of horizontal cells in the mammalian retina.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- How do horizontal cells 'talk' to cone photoreceptors? Different levels of complexity at the cone-horizontal cell synapse.The Journal of physiology · 2017Review
- Calcium-activated BKThe Journal of physiology · 2017Article
- Cell-specific cre recombinase expression allows selective ablation of glutamate receptors from mouse horizontal cells.PloS one · 2013Article
- Expression pattern of Kv11 (Ether à-go-go-related gene; erg) K+ channels in the mouse retina.PloS one · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Postsynaptic to photoreceptors, horizontal cells face prolonged exposure to glutamate in the dark. Therefore, efficient hyperpolarizing mechanisms are crucial to keep horizontal cells within an operating range and to reduce glutamate-induced excitotoxicity. Combining electrophysiology, single-cell reverse transcriptase polymerase chain reaction, and immunocytochemistry, we found that horizontal cell bodies but not their axon terminals express the ether-à-gogo-related gene isoform 1 (erg1) K(+) channel. Erg1-mediated outward currents displayed voltage-dependent activation and C-type inactivation. Recovery from inactivation involved a transient open state. Gating of erg1 channels kept the voltage response to glutamate brief and at physiological amplitudes. With erg1 channels blocked, the response of horizontal cells to the onset of darkness was significantly enhanced. These results indicate a functional dichotomy between horizontal cell bodies and axon terminals in the processing of photoreceptor signals. The dark response thus reflects a finely tuned balance determined by the successive gating of ionotropic glutamate receptors and erg1 channels.
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