ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2008
Genetic dissection of testis weight in a mouse strain having an extremely large testis: major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of quantitative trait loci determining testicular weight in DDD/Sgn inbred mice are strongly influenced by circulating testosterone levels.Asian-Australasian journal of animal sciences · 2019Article
- Genome-wide association for testis weight in the diversity outbred mouse population.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Quantitative trait loci that control body weight in DDD/Sgn and C57BL/6J inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Effect of the Y chromosome on plasma high-density lipoprotein-cholesterol levels in Y-chromosome-consomic mouse strains.BMC research notes · 2014Article
- Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains.BMC research notes · 2013Article
- Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Hermaphrodism and sex reversal associated with the dominant hemimelia mutation in XY mice.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2009Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
I investigated the potential contribution of Y-linked genes by analyzing 16 Y-consomic strains that had been established on a DH-strain background. The results provided evidence that only the Y chromosome from the C3H/HeJ strain was different from most other inbred strains. The CBA strain has the lightest testis and the DDD strain has the heaviest testis among mouse strains; however, Y-consomic analysis revealed that there were no significant differences in testis weight among DH, DH-Chr Y(DDD), and DH-Chr Y(CBA) strains, suggesting that Y(DDD) and Y(CBA) themselves do not influence testis weight. QTL analysis in DDD x DH F(2) mice identified significant testis weight QTLs on chromosomes 9, 14, and 17, and the DDD allele at all these loci was associated with an increase in testis weight. Contribution of Y chromosome itself to testis weight was thus rather modest, and therefore, major testis weight determinants are autosomal. However, it was uncertain whether there would be any effects by interactions between Y chromosomal and autosomal genes.
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