ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2008
Potassium dynamics in the epileptic cortex: new insights on an old topic.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 204 citations in OpenAlex.
- Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms.eLife · 2026Article
- Effects of Extracellular Resistance on Neuronal Sensitivity Under Weak Alternating Electric Field Stimulation: A Computational Study.Biomimetics (Basel, Switzerland) · 2026Article
- Imaging intercellular biomolecules by using fluorescent protein indicators with lipid-PEG anchors.Scientific reports · 2026Article
- Brain Extracellular Space: From an Overlooked Dimension to Catalyst of a Novel Neuroscience Paradigm.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- A conserved bioelectrical signature defines subventricular zone-derived human fetal neural stem cells and tracks their differentiation state.Frontiers in cell and developmental biology · 2026Article
- Collapsing Perisomatic Inhibition Leads to Epileptic Fast-Ripple Oscillations Caused by Pseudosynchronous Firing of CA3 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- WONOEP XVII appraisal: Targeting network excitability beyond the synapse -Neurotransmitter, ionic, and electro -diffusions.Epilepsia · 2025Review
- Virtual brain twins for stimulation in epilepsy.Nature computational science · 2025Article
- Network effects of traumatic brain injury: from infra slow to high frequency oscillations and seizures.Journal of computational neuroscience · 2025Article
- Virtual epilepsy patient cohort: Generation and evaluation.PLoS computational biology · 2025Article
- Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Increased robustness and adaptation to simultaneous temperature and elevated extracellular potassium in the pyloric rhythm of the crab,Journal of neurophysiology · 2025Article
- Ion concentrations in CSF and serum are differentially and precisely regulated.Brain communications · 2025Article
- The hydroxycarboxylic acid receptor HCA2 is required for the protective effect of ketogenic diet in epilepsy.Pharmacology research & perspectives · 2024Article
- Article
- Uncertainty quantification and sensitivity analysis of neuron models with ion concentration dynamics.PloS one · 2024Article
- Local extracellular KProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Metabolic implications of axonal demyelination and its consequences for synchronized network activity: AnJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.Nature communications · 2023Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The role of changes in the extracellular potassium concentration [K(+)](o) in epilepsy has remained unclear. Historically, it was hypothesized that [K(+)]( o) is the causal factor for epileptic seizures. This so-called potassium accumulation hypothesis led to substantial debate but subsequently failed to find wide acceptance. However, recent studies on the pathophysiology of tissue from epileptic human patients and animal epilepsy models revealed aberrations in [K(+)](o) regulation. Computational models of cortical circuits that include ion concentration dynamics have catalyzed a renewed interest in the role of [K(+)](o) in epilepsy. The authors here connect classical and more recent insights on [K(+)]( o) dynamics in the cortex with the goal of providing starting points for a next generation of [K(+)](o) research. Such research may ultimately lead to an entirely new class of antiepileptic drugs that act on the [K(+)](o) regulation system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.