ArticleApplied and environmental microbiology2009
Two dissimilar N-acyl-homoserine lactone acylases of Pseudomonas syringae influence colony and biofilm morphology.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 115 citations in OpenAlex.
- Quercetin as a selective quorum sensing inhibitor: in silico and in vitro analyses against Pseudomonas syringae with limited impact on plant growth-promoting bacteria.Molecular diversity · 2026Article
- Quorum quenching pathoblockers from bacteria: an alternative approach for bacterial infection management.Folia microbiologica · 2026Review
- A critical review of natural quorum-sensing inhibitors as molecular anti-virulence agents against phytopathogenic bacteria.Archives of microbiology · 2026Review
- Article
- Beyond Antibiotics: What the Future Holds.Antibiotics (Basel, Switzerland) · 2024Review
- Quorum Quenching Approaches against Bacterial-Biofilm-Induced Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Diversity of Bacteria with Quorum Sensing and Quenching Activities from Hydrothermal Vents in the Okinawa Trough.Microorganisms · 2023Article
- A Bacterial Isolate Capable of Quenching Both Diffusible Signal Factor- andJournal of agricultural and food chemistry · 2022Article
- Quorum Quenching Strains Isolated from the Microbiota of Sea Anemones and Holothurians AttenuateMicroorganisms · 2022Article
- Bile Salt Hydrolase Degrades β-Lactam Antibiotics and Confers Antibiotic Resistance onFrontiers in microbiology · 2022Article
- Innovative microbial disease biocontrol strategies mediated by quorum quenching and their multifaceted applications: A review.Frontiers in plant science · 2022Review
- Correlation Analysis between Chronic Osteomyelitis and Bacterial Biofilm.Stem cells international · 2022Article
- Novel Bifunctional Acylase fromAntibiotics (Basel, Switzerland) · 2021Article
- Review
- AHL-Lactonase ProducingFrontiers in microbiology · 2021Article
- N-Acyl Homoserine Lactones and Lux Solos Regulate Social Behaviour and Virulence of Pseudomonas syringae pv. actinidiae.Microbial ecology · 2020Article
- Quorum Quenching: A Potential Target for Antipseudomonal Therapy.Infection and drug resistance · 2020Review
- Competition/antagonism associations of biofilm formation among Staphylococcus epidermidis Agr groups I, II, and III.Journal of microbiology (Seoul, Korea) · 2019Article
- Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression.Journal, genetic engineering & biotechnology · 2018Review
- Quorum-Quenching Bacteria Isolated From Red Sea Sediments Reduce Biofilm Formation byFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant aerial surfaces comprise a complex habitat for microorganisms, and many plant-associated bacteria, such as the pathogen Pseudomonas syringae, exhibit density-dependent survival on leaves by utilizing quorum sensing (QS). QS is often mediated by diffusible signals called N-acyl-homoserine lactones (AHLs), and P. syringae utilizes N-3-oxo-hexanoyl-dl-homoserine lactone (3OC6HSL) to control traits influencing epiphytic fitness and virulence. The P. syringae pathovar syringae B728a genome sequence revealed two putative AHL acylases, termed HacA (Psyr_1971) and HacB (Psyr_4858), which are N-terminal nucleophile hydrolases that inactivate AHLs by cleaving their amide bonds. HacA is a secreted AHL acylase that degrades only long-chain (C > or = 8) AHLs, while HacB is not secreted and degrades all tested AHLs. Targeted disruptions of hacA, hacB, and hacA and hacB together do not alter endogenous 3OC6HSL levels under the tested conditions. Surprisingly, targeted disruptions of hacA alone and hacA and hacB together confer complementable phenotypes that are very similar to autoaggregative phenotypes seen in other species. While AHL acylases might enable P. syringae B728a to degrade signals of competing species and block expression of their QS-dependent traits, these enzymes also play fundamental roles in biofilm formation.
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