Evidence map›Paper›PMID 18997020›Full record

ArticleApplied and environmental microbiology2009

The plasmid-encoded regulator activates factors conferring lysozyme resistance on enteropathogenic Escherichia coli strains.

Nina Salinger, Bashkim Kokona, Robert Fairman, Iruka N Okeke

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Diarrheagenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nina SalingerDepartment of Biology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041, USA.
Bashkim Kokona
Robert Fairman
Iruka N Okeke
Haverford College · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

We demonstrate that enhanced lysozyme resistance of enteropathogenic Escherichia coli requires the plasmid-encoded regulator, Per, and is mediated by factors outside the locus for enterocyte effacement. EspC, a Per-activated serine protease autotransporter protein, conferred enhanced resistance on nonpathogenic E. coli, and a second Per-regulated, espC-independent lysozyme resistance mechanism was identified.

Indexed as

Drug Resistance, BacterialPlasmidsAmino Acid SequenceAnti-Bacterial AgentsEnteropathogenic Escherichia coliEscherichia coli ProteinsHumansMicrobial Sensitivity TestsMicrobial ViabilityMolecular Sequence DataMuramidaseTranscription FactorsAnti-Bacterial AgentsEscherichia coli ProteinsEspC protein, E coliMuramidaseTranscription Factors

Identifiers

PMID18997020
PMCPMC2612221
OpenAlexW2129759529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.