ArticleGenome research2009
Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
- Mapping the landscape of allele-specific expression in porcine genomes.Genome biology · 2026Article
- Genetic Evidence Reveals Causal Effect of Circulating Proteome on Random Glucose: A Mendelian Randomization Study.Journal of diabetes research · 2026Article
- Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients.HemaSphere · 2025Article
- From early methods for DNA diagnostics to genomes and epigenomes at high resolution during four decades - a personal perspective.Upsala journal of medical sciences · 2024Review
- Acute lymphoblastic leukemia displays a distinct highly methylated genome.Nature cancer · 2022Article
- Changes in DNA Methylation in Response to 6-Benzylaminopurine Affect Allele-Specific Gene Expression inInternational journal of molecular sciences · 2020Article
- Monoallelic expression in melanoma.Journal of translational medicine · 2019Article
- Article
- Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity.European child & adolescent psychiatry · 2018Article
- Crosstalk of Genetic Variants, Allele-Specific DNA Methylation, and Environmental Factors for Complex Disease Risk.Frontiers in genetics · 2018Review
- Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy.Journal of muscle research and cell motility · 2017Article
- Allele-specific expression at the androgen receptor alpha gene in a hybrid unisexual fish, the Amazon molly (Poecilia formosa).PloS one · 2017Article
- Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test.BMC proceedings · 2016Article
- Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia.Cancer science · 2015Article
- Identification of regulatory SNPs associated with genetic modifications in lung adenocarcinoma.BMC research notes · 2015Article
- Recommendations for Accurate Resolution of Gene and Isoform Allele-Specific Expression in RNA-Seq Data.PloS one · 2015Article
- SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data.Nucleic acids research · 2014Article
- Dissecting the causal genetic mechanisms of coronary heart disease.Current atherosclerosis reports · 2014Review
- Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes.PloS one · 2014Article
- Bulk segregant RNA-seq reveals expression and positional candidate genes and allele-specific expression for disease resistance against enteric septicemia of catfish.BMC genomics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
Abstract
To identify genes that are regulated by cis-acting functional elements in acute lymphoblastic leukemia (ALL) we determined the allele-specific expression (ASE) levels of 2, 529 genes by genotyping a genome-wide panel of single nucleotide polymorphisms in RNA and DNA from bone marrow and blood samples of 197 children with ALL. Using a reproducible, quantitative genotyping method and stringent criteria for scoring ASE, we found that 16% of the analyzed genes display ASE in multiple ALL cell samples. For most of the genes, the level of ASE varied largely between the samples, from 1.4-fold overexpression of one allele to apparent monoallelic expression. For genes exhibiting ASE, 55% displayed bidirectional ASE in which overexpression of either of the two SNP alleles occurred. For bidirectional ASE we also observed overall higher levels of ASE and correlation with the methylation level of these sites. Our results demonstrate that CpG site methylation is one of the factors that regulates gene expression in ALL cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.