ArticleNucleic acids research2009
siRecords: a database of mammalian RNAi experiments and efficacies.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database.IET systems biology · 2024Article
- siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A database of breast oncogenic specific siRNAs.Scientific reports · 2017Article
- NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.Nucleic acids research · 2017Article
- SMEpred workbench: A web server for predicting efficacy of chemicallymodified siRNAs.RNA biology · 2016Article
- siRNAmod: A database of experimentally validated chemically modified siRNAs.Scientific reports · 2016Article
- Computational design of artificial RNA molecules for gene regulation.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Target gene abundance contributes to the efficiency of siRNA-mediated gene silencing.Nucleic acid therapeutics · 2014Article
- RNAiAtlas: a database for RNAi (siRNA) libraries and their specificity.Database : the journal of biological databases and curation · 2012Article
- HIVsirDB: a database of HIV inhibiting siRNAs.PloS one · 2011Article
- Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study.BMC bioinformatics · 2010Article
- Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.Cancer metastasis reviews · 2010Review
- Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency.Bioinformatics (Oxford, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
RNAi-based gene-silencing techniques offer a fast and cost-effective way of knocking down genes' functions in an easily regulated manner. Exciting progress has been made in recent years in the application of these techniques in basic biomedical research and therapeutic development. However, it remains a difficult task to design effective siRNA experiments with high efficacy and specificity. We present siRecords, an extensive database of mammalian RNAi experiments with consistent efficacy ratings. This database serves two purposes. First, it provides a large and diverse dataset of siRNA experiments. This dataset faithfully represents the general, diverse RNAi experimental practice, and allows more reliable siRNA design tools to be developed with the overfitting problem well curbed. Second, the database helps experimental RNAi researchers directly by providing them with the efficacy and other information about the siRNAs experiments designed and conducted previously against the genes of their interest. The current release of siRecords contains the records of 17,192 RNAi experiments targeting 5086 genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.