ArticleThe American journal of clinical nutrition2008
Entero-insular axis and postprandial insulin differences in African American and European American children.
Article in The American journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity.Journal of diabetes research · 2019Pooled it
- Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men.BMJ open diabetes research & care · 2021Observational
- Sex and Race Predict Adverse Outcomes Following Bariatric Surgery: an MBSAQIP Analysis.Obesity surgery · 2020Article
- Postprandial Insulin Response and Clearance Among Black and White Women: The Federal Women's Study.The Journal of clinical endocrinology and metabolism · 2019Article
- Differences in β-cell function and insulin secretion in Black vs. White obese adolescents: do incretin hormones play a role?Pediatric diabetes · 2017Article
- Ethnic differences in insulin sensitivity and beta-cell function among Asian men.Nutrition & diabetes · 2015Article
- Racial/Ethnic Differences in Insulin Resistance and Beta Cell Function: Relationship to Racial Disparities in Type 2 Diabetes among African Americans versus Caucasians.Current obesity reports · 2015Review
- Article
- Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality.The Journal of clinical endocrinology and metabolism · 2014Article
- Use of a simple liquid meal test to evaluate insulin sensitivity and beta-cell function in children.Pediatric obesity · 2014Article
- Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition.PloS one · 2014Article
- The dipeptidyl peptidase (DPP)-4 inhibitors for type 2 diabetes mellitus in challenging patient groups.Advances in therapy · 2013Review
- Clinical characteristics of the responders to dipeptidyl peptidase-4 inhibitors in Korean subjects with type 2 diabetes.Journal of Korean medical science · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAfrican Americans have a greater insulin response after glucose challenge than do European Americans. Factors underlying this response are unknown.
objectiveWe determined the insulin, C-peptide, and incretin responses to a mixed macronutrient meal in African American and European American children. We hypothesized that 1) African Americans would have greater postprandial insulin and C-peptide responses, 2) African Americans would have higher incretin responses, and 3) the greater beta cell response among African Americans would be explained by greater incretin responses.
designSubjects were 34 African American and 18 European American children. Glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were measured after the subjects consumed a liquid mixed meal. Insulin, C-peptide, and incretin responses were derived from the area under the curve (AUC) for minutes 0-30 (early response) and minutes 30-180 (late response) after meal ingestion.
resultsThe early insulin response was higher in African American (14,565 +/- 6840 pmol/L x 30 min) than in European American (7450 +/- 4077 pmol/L x 30 min; P < 0.01) children. Early C-peptide AUC did not differ by ethnicity (African Americans: 34.8 +/- 12.5; European Americans: 28.6 +/- 12.5 nmol/L x 30 min; P = 0.10). Early and late GLP-1 responses were lower in African Americans than in European Americans: 108.1 +/- 56.4 compared with 160.5 +/- 90.8 pmol/L x 30 min and 509.4 +/- 286.9 compared with 781.9 +/- 483.4 pmol/L x 150 min, respectively (P < 0.05 for both). The GIP response did not differ between groups.
conclusionsThe greater early insulin response in African Americans than in European Americans is not due to differences in circulating GLP-1 or GIP and may be due to lesser insulin clearance. Further research is needed to determine the physiologic implications of lower GLP-1 among African Americans.
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