ReviewProstaglandins, leukotrienes, and essential fatty acids
Trans fatty acids: effects on cardiometabolic health and implications for policy.
Review in Prostaglandins, leukotrienes, and essential fatty acids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 182 citations in OpenAlex.
- Ion Mobility-Mass Spectrometry Imaging: Advances in Biomedical Research.Biotech (Basel (Switzerland)) · 2025Review
- Trans-Fatty Acids (TFA) Induced Vascular Injury Through the Regulation of the Sirt1-Ppargc1a-Nfe2l2 Signaling Pathway in Male Rats.Food science & nutrition · 2025Article
- Article
- Current Insights into Industrial Trans Fatty Acids Legal Frameworks and Health Challenges in the European Union and Spain.Foods (Basel, Switzerland) · 2024Article
- Maternal Nutrition during Pregnancy and Offspring Brain Development: Insights from Neuroimaging.Nutrients · 2024Review
- Assessing the Hypertension Risk: A Deep Dive into Cereal Consumption and Cooking Methods-Insights from China.Nutrients · 2024Article
- Associations between trans fatty acids and systemic immune-inflammation index: a cross-sectional study.Lipids in health and disease · 2024Article
- A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs.Scientific reports · 2023Article
- Trans fatty acid intake increases likelihood of dyslipidemia especially among individuals with higher saturated fat consumption.Reviews in cardiovascular medicine · 2022Article
- Molecular Approaches Reduce Saturates and EliminateFrontiers in plant science · 2022Review
- Unhealthy Dietary Habits and Obesity: The Major Risk Factors Beyond Non-Communicable Diseases in the Eastern Mediterranean Region.Frontiers in nutrition · 2022Review
- Recent Advances on Pickering Emulsions Stabilized by Diverse Edible Particles: Stability Mechanism and Applications.Frontiers in nutrition · 2022Review
- The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns.Foods (Basel, Switzerland) · 2021Review
- Trans Fat Free by 2023-A Building Block of the COVID-19 Response.Frontiers in nutrition · 2021Article
- Trans fatty acid elimination policy in member states of the Eurasian Economic Union: Implementation challenges and capacity for enforcement.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Fatty Acid Composition of Meat and Edible Offal from Free-Living Red Deer (Foods (Basel, Switzerland) · 2020Article
- The biochemistry of headgroup exchange during triacylglycerol synthesis in canola.The Plant journal : for cell and molecular biology · 2020Article
- Plasma Trans Fatty Acid Levels, Cardiovascular Risk Factors and Lifestyle: Results from the Akershus Cardiac Examination 1950 Study.Nutrients · 2020Article
- Review
- Stress, Dietary Patterns and Cardiovascular Disease: A Mini-Review.Frontiers in neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In both developed and developing countries, trans fatty acids (TFA) are largely consumed from partially hydrogenated vegetable oils. This article focuses on TFA as a modifiable dietary risk factor for cardiovascular disease, reviewing the evidence for lipid and non-lipid effects; the relations of trans fat intake with clinical endpoints; and current policy and legislative issues. In both observational cohort studies and randomized clinical trials, TFA adversely affect lipid profiles (including raising LDL and triglyceride levels, and reducing HDL levels), systemic inflammation, and endothelial function. More limited but growing evidence suggests that TFA also exacerbate visceral adiposity and insulin resistance. These potent effects of TFA on a multitude of cardiovascular risk factors are consistent with the strong associations seen in prospective cohort studies between TFA consumption and risk of myocardial infarction and coronary heart disease (CHD) death. The documented harmful effects of TFA along with the feasibility of substituting partially hydrogenated vegetable oils with healthy alternatives indicate little reason for continued presence of industrially produced TFA in food preparation and manufacturing or in home cooking fats/oils. A comprehensive strategy to eliminate the use of industrial TFA in both developed and developing countries, including education, food labeling, and policy and legislative initiatives, would likely prevent tens of thousands of CHD events worldwide each year.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.