ReviewBiochimica et biophysica acta2010
Formins in development: orchestrating body plan origami.
Review in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- A Comparative Study of the Role of Formins inCells · 2022Article
- TheFrontiers in plant science · 2021Article
- Review
- The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice.The Journal of biological chemistry · 2018Article
- Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins.Scientific reports · 2017Article
- A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo.Development (Cambridge, England) · 2016Article
- TheeLife · 2016Article
- Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.Genetics · 2016Article
- Article
- Article
- Article
- FHOD proteins in actin dynamics--a formin' class of its own.Small GTPases · 2014Review
- Functional analysis of BcBem1 and its interaction partners in Botrytis cinerea: impact on differentiation and virulence.PloS one · 2014Article
- Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.Biology open · 2012Article
- Cytoskeleton responses in wound repair.Cellular and molecular life sciences : CMLS · 2012Review
- The formin FMNL3 is a cytoskeletal regulator of angiogenesis.Journal of cell science · 2012Article
- Formins: emerging players in the dynamic plant cell cortex.Scientifica · 2012Review
- Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.The Journal of biological chemistry · 2010Article
- The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni.PloS one · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Formins, proteins defined by the presence of an FH2 domain and their ability to nucleate linear F-actin de novo, play a key role in the regulation of the cytoskeleton. Initially thought to primarily regulate actin, recent studies have highlighted a role for formins in the regulation of microtubule dynamics, and most recently have uncovered the ability of some formins to coordinate the organization of both the microtubule and actin cytoskeletons. While biochemical analyses of this family of proteins have yielded many insights into how formins regulate diverse cytoskeletal reorganizations, we are only beginning to appreciate how and when these functional properties are relevant to biological processes in a developmental or organismal context. Developmental genetic studies in fungi, Dictyostelium, vertebrates, plants and other model organisms have revealed conserved roles for formins in cell polarity, actin cable assembly and cytokinesis. However, roles have also been discovered for formins that are specific to particular organisms. Thus, formins perform both global and specific functions, with some of these roles concurring with previous biochemical data and others exposing new properties of formins. While not all family members have been examined across all organisms, the analyses to date highlight the significance of the flexibility within the formin family to regulate a broad spectrum of diverse cytoskeletal processes during development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.