ArticleInternational journal of hygiene and environmental health2009
Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.
Article in International journal of hygiene and environmental health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 52 citations in OpenAlex.
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- Levels of Mercury in Fish-Eating Children, With and Without Amalgam Restoration.Journal of pharmacy & bioallied sciences · 2019Article
- Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes.Toxicology reports · 2019Article
- Toxic metals in topsoil under different land uses from Xiandao District, middle China: distribution, relationship with soil characteristics, and health risk assessment.Environmental science and pollution research international · 2015Article
- Spatial distribution and health risk assessment of toxic metals associated with receptor population density in street dust: a case study of Xiandao District, Changsha, Middle China.Environmental science and pollution research international · 2015Article
- High-field MRI and mercury release from dental amalgam fillings.The international journal of occupational and environmental medicine · 2014Article
- Spatial distribution, bioavailability, and health risk assessment of soil Hg in Wuhu urban area, China.Environmental monitoring and assessment · 2011Article
- Mercury exposure and children's health.Current problems in pediatric and adolescent health care · 2010Review
- Mercury exposure levels in children with dental amalgam fillings.International journal of clinical pediatric dentistryArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeA scientific review panel for the US Food and Drug Administration (FDA) recently identified the need for more data on the health risk of mercury exposure from dental amalgam among susceptible populations. We evaluated impacts of low-level mercury exposure on renal function and neurobehavioral and neuropsychological performance among children.
methodsDental histories for 403 children aged 7-11 years in five schools from Xuhui, Shanghai were checked by dentists. Of them, 198 with confirmed amalgam fillings were recruited (exposure group). Reference children (N=205) were those who never had dental amalgam treatment. In May 2004, each child provided a urine sample for measurements of total mercury, N-acetyl-beta-D-glucosaminidase activity, microalbumin, and creatinine (Cr). The Child Behavior Checklist, Eysenck Personality Questionnaire, and an intelligence screening test were administered.
resultsThe geometric mean urinary mercury concentration was 1.6 microg/g Cr for children with and 1.4 microg/g Cr for children without amalgam fillings. No differences were found between children with and without fillings for either renal function biomarker, or on neurobehavioral, neuropsychological, or intelligence tests.
conclusionsAlthough urinary mercury concentration was slightly elevated among children with amalgam fillings, we found no evidence of adverse effects on the outcomes evaluated. These results agree with those from recent trials in developed countries.
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