Evidence map›Paper›PMID 18995183›Full record

ArticleJournal of cardiac failure2008

Improvements in signs and symptoms during hospitalization for acute heart failure follow different patterns and depend on the measurement scales used: an international, prospective registry to evaluate the evolution of measures of disease severity in acute heart failure (MEASURE-AHF).

Larry A Allen, Marco Metra, Olga Milo-Cotter, Gerasimos Filippatos, Leonardo H Reisin, Daniel R Bensimhon, Edoardo G Gronda, Paolo Colombo, G Michael Felker, Livio Dei Cas and 6 more

Registry-linked trialAbstract readComparative StudyEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiac failure, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02767024 (Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Reduced Ejection Fraction and Acute Decompensation With Low Cardiac Output), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02767024 phase4withdrawnnot on this mapstarted 2018, after this paper: background citation

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Reduced Ejection Fraction and Acute Decompensation With Low Cardiac Output: A Single Center, Randomized, Non-Blinded, and Parallel Study (PRIORITY-ADHF Study)

TypeinterventionalSponsorMontefiore Medical CenterRan2018 to 2018Enrolled0ConditionsAcute Heart FailureArmsSodium nitroprusside, Dobutamine, Furosemide
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Lack of correlation between different congestion markers in acute decompensated heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
  7. Repetitive levosimendan treatment in the management of advanced heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2018
    Article
  8. Article
  9. Review
  10. Diagnosis and management of acute heart failure.Anatolian journal of cardiology · 2015
    Article
  11. Review
  12. Review
  13. Assessment of dyspnea early in acute heart failure: patient characteristics and response differences between likert and visual analog scales.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2014
    Article
  14. Review
  15. Review
  16. Article
  17. End points for clinical trials in acute heart failure syndromes.Journal of the American College of Cardiology · 2009
    Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 4 countries.

Larry A AllenDivision of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA. larry_allen@post.harvard.edu
Marco Metra
Olga Milo-Cotter
Gerasimos Filippatos
Leonardo H Reisin
Daniel R Bensimhon
Edoardo G Gronda
Paolo Colombo
G Michael Felker
Livio Dei Cas
Dimitrios T Kremastinos
Christopher M O'Connor
Gadi Cotter
Beth A Davison
Howard C Dittrich
Eric J Velazquez
University of Brescia · ITDuke Medical Center · USMomentum Research · USUniversity General Hospital Attikon · GRBarzilai Medical Center · ILClinical Research Institute · USColumbia University Irving Medical Center · USCone Health · USFondazione Humanitas per la Ricerca · ITUniversity of Colorado Denver · US

Funding

Postdoctoral Training in Cardiovascular Clinical ResearchT32HL069749 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2003 to 2023
$6.7M
NHLBI NIH HHS T32 HL069749
6 · The paper itself

Abstract

backgroundThe natural evolution of signs and symptoms during acute heart failure (AHF) is poorly characterized. METHODS AND

resultsWe followed a prospective international cohort of 182 patients hospitalized with AHF. Patient-reported dyspnea and general well-being (GWB) were measured daily using 7-tier Likert (-3 to +3) and visual analog scales (VAS, 0-100). Physician assessments were also recorded daily. Mean age was 69 years and 68% had ejection fraction <40%. Likert measures of dyspnea initially improved rapidly (day 1, 0.22; day 2, 1.31; P <.001) with no significant improvement thereafter (day 7, 1.51; day 2 versus 7 P = .16). In contrast, VAS measure of dyspnea improved throughout hospitalization (day 1, 50.1; day 2, 64.7; day 7, 83.2; day 1 versus 2 P < .001, day 2 versus 7 P < .001). Symptoms of dyspnea and GWB tracked closely (correlation r = .813, P < .001). Physical signs resolved more completely than did symptoms (eg, from day 1 to discharge/day 7, absence of edema increased from 33% to 72% of patients, whereas significant improvements in dyspnea increased from 27% to 52% of patients; P < .001).

conclusionsChanges in patient-reported symptoms and physician-assessed signs followed different patterns during an AHF episode and are influenced by the measurement scales used. Multiple clinical measures should be considered in discharge decisions and evaluation of AHF therapies.

Indexed as

InternationalitySeverity of Illness IndexAcute DiseaseAgedAged, 80 and overCohort StudiesFemaleHeart FailureHumansMaleMiddle AgedPatient AdmissionPatient DischargeProspective StudiesRegistriesWeights and Measures

Identifiers

PMID18995183
PMCPMC3961584
OpenAlexW2169475898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.