ArticleThe Biochemical journal1991
Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.
Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Monocyte and macrophage dynamics during atherogenesis.Arteriosclerosis, thrombosis, and vascular biology · 2011Review
- Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia.Leukemia research · 2009Article
- Leukemic stem cells: where do they come from?Stem cell reviews · 2005Review
- Modeling Philadelphia chromosome positive leukemias.Oncogene · 2001Review
- Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.The Biochemical journal · 1993Article
- Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.The Biochemical journal · 1992Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA. Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased. The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction. These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.
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Registered trials
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