ArticleImmunity2008
Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.
Article in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus.Nature communications · 2022Article
- How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla.Frontiers in immunology · 2022Article
- Article
- Central CD4Nature reviews. Immunology · 2019Review
- STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes.Cell calcium · 2018Review
- ZAP-70 in Signaling, Biology, and Disease.Annual review of immunology · 2018Review
- Mechanosensing drives acuity ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- CD6 modulates thymocyte selection and peripheral T cell homeostasis.The Journal of experimental medicine · 2016Article
- Article
- Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Nature immunology · 2014Article
- A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.Immunity · 2013Article
- Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ.Science signaling · 2013Article
- T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.The Journal of biological chemistry · 2013Article
- Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.Immunity · 2013Article
- How the immune system talks to itself: the varied role of synapses.Immunological reviews · 2013Review
- T cell antigen recognition at the cell membrane.Molecular immunology · 2012Review
- Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells.Immunologic research · 2011Article
- Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Immature double-positive (CD4(+)CD8(+)) thymocytes respond to negatively selecting peptide-MHC ligands by forming an immune synapse that sustains contact with the antigen-presenting cell (APC). Using fluorescently labeled peptides, we showed that as few as two agonist ligands could promote APC contact and subsequent apoptosis in reactive thymocytes. Furthermore, we showed that productive signaling for positive selection, as gauged by nuclear translocation of a green fluorescent protein (GFP)-labeled NFATc construct, did not involve formation of a synapse between thymocytes and selecting epithelial cells in reaggregate thymus cultures. Antibody blockade of endogenous positively selecting ligands prevented NFAT nuclear accumulation in such cultures and reversed NFAT accumulation in previously stimulated thymocytes. Together, these data suggest a "gauntlet" model in which thymocytes mature by continually acquiring and reacquiring positively selecting signals without sustained contact with epithelial cells, thereby allowing them to sample many cell surfaces for potentially negatively selecting ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.