ArticleThe Journal of allergy and clinical immunology2008
The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project.
Article in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
113 citing papers in PubMed, 3 syntheses or guidelines pooled it, 412 citations in OpenAlex.
- Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community.The Cochrane database of systematic reviews · 2012Pooled it
- Glucocorticoids for the treatment of anaphylaxis.The Cochrane database of systematic reviews · 2012Pooled it
- Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel.The Journal of allergy and clinical immunology · 2010Guideline
- Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy.The Journal of allergy and clinical immunology · 2015Trial
- Trial
- Recent Updates in the Management of Anaphylaxis: The Role of the Pediatrician.Journal of pediatrics. Clinical practice · 2026Article
- Using Biologics in the Prevention of Anaphylaxis.Current allergy and asthma reports · 2025Review
- Article
- Public Knowledge and Management Practices of Anaphylaxis in Al-Ahsa, Saudi Arabia: A Cross-Sectional Study.Cureus · 2025Article
- Incidence and trends of anaphylaxis among inpatients from 2003 to 2023 in Wuhan, China: A multicenter retrospective study.The World Allergy Organization journal · 2024Article
- Using the Right Criteria for MCAS.Current allergy and asthma reports · 2024Review
- Predictors of Clonality and Underlying Mastocytosis in Mast Cell Activation Syndromes.Current allergy and asthma reports · 2024Review
- A Puzzling Mast Cell Trilogy: Anaphylaxis, MCAS, and Mastocytosis.Diagnostics (Basel, Switzerland) · 2023Review
- Development of a machine learning algorithm based on administrative claims data for identification of ED anaphylaxis patient visits.The journal of allergy and clinical immunology. Global · 2023Article
- Improving Methods of Identifying Anaphylaxis for Medical Product Safety Surveillance Using Natural Language Processing and Machine Learning.American journal of epidemiology · 2023Article
- Population-based incidence of all-cause anaphylaxis and its development over time: a systematic review and meta-analysis.Frontiers in allergy · 2023Review
- Trifuhalol A Suppresses Allergic Inflammation through Dual Inhibition of TAK1 and MK2 Mediated by IgE and IL-33.International journal of molecular sciences · 2022Article
- Risk factors of anaphylaxis in Korea: Identifying drug-induced anaphylaxis culprits using big data.Medicine · 2022Article
- Anaphylactic reactions in the build-up phase of rush immunotherapy for bee venom allergy in pediatric patients: a single-center experience.Clinical and molecular allergy : CMA · 2022Article
- Acute Urticaria and Anaphylaxis: Differences and Similarities in Clinical Management.Frontiers in allergy · 2022Review
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundReported incidences of anaphylaxis range from 3.2 to 20 per 100,000 population. The incidence and trend over time has meaningful public health implications but has not been well characterized because of a lack of a standard definition and deficiencies in reporting of events.
objectiveWe sought to determine the incidence and cause of anaphylaxis over a 10-year period.
methodsWe performed a population-based incidence study that was conducted in Rochester, Minnesota, from 1990 through 2000. Anaphylaxis episodes were identified on the basis of symptoms and signs of mast cell and basophil mediator release plus mucocutaneous, gastrointestinal tract, respiratory tract, or cardiovascular system involvement.
resultsTwo hundred eleven cases of anaphylaxis were identified (55.9% in female subjects). The mean age was 29.3 years (SD, 18.2 years; range, 0.8-78.2 years). The overall age- and sex-adjusted incidence rate was 49.8 (95% CI, 45.0-54.5) per 100,000 person-years. Age-specific rates were highest for ages 0 to 19 years (70 per 100,000 person-years). Ingested foods accounted for 33.2% (70 cases), insect stings accounted for 18.5% (39 cases), medication accounted for 13.7% (29 cases), radiologic contrast agent accounted for 0.5% (1 case), "other" causes accounted for 9% (19 cases), and "unknown" causes accounted for 25.1% (53 cases). The "other" group included cats, latex, cleaning agents, environmental allergens, and exercise. There was an increase in the annual incidence rate during the study period from 46.9 per 100,000 persons in 1990 to 58.9 per 100,000 persons in 2000 (P = .03).
conclusionThe overall incidence rate is 49.8 per 100,000 person-years, which is higher than previously reported. The annual incidence rate is also increasing. Food and insect stings continue to be major inciting agents for anaphylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.