ReviewSeminars in cell & developmental biology2009
Steroid signaling and temperature-dependent sex determination-Reviewing the evidence for early action of estrogen during ovarian determination in turtles.
Review in Seminars in cell & developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 103 citations in OpenAlex.
- Integrated Transcriptome Landscape of mRNAs, lncRNAs, circRNAs, and miRNAs Reveals Molecular Regulatory Networks of Sex Differentiation in the Zig-Zag Eel (International journal of molecular sciences · 2026Article
- Estrogen receptor and temperature independently influence sex determination in the red-eared slider turtle.Frontiers in endocrinology · 2025Article
- Role ofInternational journal of molecular sciences · 2023Article
- Chronology of embryonic and gonadal development in the Reeves' turtle, Mauremys reevesii.Scientific reports · 2022Article
- Role ofZoological research · 2022Article
- Oestrogen Activates the MAP3K1 Cascade and β-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line.International journal of molecular sciences · 2021Article
- Sex determination without sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Assessing the Ability of Developmentally Precocious Estrogen Signaling to Recapitulate Ovarian Transcriptomes and Follicle Dynamics in Alligators from a Contaminated Lake.Environmental health perspectives · 2020Article
- Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line.BMC molecular and cell biology · 2020Article
- Chronology of Gonadal Development in the Malayan Snail-eating TurtleZoological studies · 2020Article
- Role for androgens in determination of ovarian fate in the common snapping turtle, Chelydra serpentina.General and comparative endocrinology · 2019Article
- Some like it dry: Water restriction overrides heterogametic sex determination in two reptiles.Ecology and evolution · 2019Article
- Caste-specific development of the dopaminergic system during metamorphosis in female honey bees.PloS one · 2018Article
- Improved genome assembly of American alligator genome reveals conserved architecture of estrogen signaling.Genome research · 2017Article
- Stable Cretaceous sex chromosomes enable molecular sexing in softshell turtles (Testudines: Trionychidae).Scientific reports · 2017Article
- Article
- Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination.Endocrinology · 2015Article
- A comprehensive transcriptome provides candidate genes for sex determination/differentiation and SSR/SNP markers in yellow catfish.Marine biotechnology (New York, N.Y.) · 2015Article
- The concept of the sexual reproduction cycle and its evolutionary significance.Frontiers in plant science · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The developmental processes underlying gonadal differentiation are conserved across vertebrates, but the triggers initiating these trajectories are extremely variable. The red-eared slider turtle (Trachemys scripta elegans) exhibits temperature-dependent sex determination (TSD), a system where incubation temperature during a temperature-sensitive period of development determines offspring sex. However, gonadal sex is sensitive to both temperature and hormones during this period-particularly estrogen. We present a model for temperature-based differences in aromatase expression as a critical step in ovarian determination. Localized estrogen production facilitates ovarian development while inhibiting male-specific gene expression. At male-producing temperatures aromatase is not upregulated, thereby allowing testis development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.